Difference between revisions of "Extrinsic Allergic Bronchio-Alveolitis"
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[[Category:Allergic Respiratory Diseases]] | [[Category:Allergic Respiratory Diseases]] | ||
[[Category:Respiratory Diseases - Cattle]] | [[Category:Respiratory Diseases - Cattle]] | ||
| − | [[Category:To Do - Blood]][[Category:To Do - | + | [[Category:To Do - Blood]][[Category:To Do - Clinical]] |
[[Category:Type III Hypersensitivity Diseases]] | [[Category:Type III Hypersensitivity Diseases]] | ||
[[Category:Bronchi and Bronchioles - Pathology]] | [[Category:Bronchi and Bronchioles - Pathology]] | ||
[[Category:Respiratory System - Inflammatory Pathology]] | [[Category:Respiratory System - Inflammatory Pathology]] | ||
Revision as of 17:19, 19 February 2011
- Synonym: Bovine Farmers Lung
- Arises due to repeated inhalation of spores of thermophilic actinomycetes in mouldy hay (Micropolyspora faeni and Thermactinomyces vulgaris)
- Can be experimentally reproduced by repeated exposure to M. faeni aerosols
- Disease primarily of housed animals in winter
- Spores can penetrate to the level of terminal bronchioles and alveoli throughout the lung
- Pathogenesis results from a type III (Arthus) hypersensitivity reaction to the inhaled fungal spores
- Macroscopically:
- Lungs appear normal however on close inspection, numerous small grey nodules representing lymphoid reaction are evident
- Histologically:
- Lymphocytic/plasmacytic bronchitis/ bronchiolitis
- Associated thickening of the alveolar septae
- In severe and chronic disease, the lesions can progress to severe interstitial fibrosis and type II hyperplasia
- In extreme cases, vascular compromise may -> pulmonary hypertension -> cor pulmonale