Difference between revisions of "Skin Congenital and Hereditary - Pathology"

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#REDIRECT[[:Category:Integumentary System - Pathology]]
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===[[Acanthosis Nigricans]]===
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===[[Alopecia and Hypotrichosis]]===
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===[[Collagen Dysplasia]]===
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===Epidermolysis Bullosa===
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[[Image: Epidermolysis bullosa.jpg|100px|thumb|right|<small><center>Epidermolysis bullosa in a lamb (Courtesy of Bristol BioMed Image Archive)</center></small>]]
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*Also called '''Red Foot Disease'''
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*Occurs in sheep, dogs, cattle and horses
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*Development of cutaneous blisters
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*Varies depending on hereditary cause
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*Affected animals tend not to survive
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*Lesions appear at surfaces that are easily damaged, ''e.g.'' oral mucosa, feet
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*Microscopically:
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**Epidermal vesicular disease
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**Healing displaces lesions more dorsally
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**May become infected and form [[Skin Glossary - Pathology|pustules]]
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[[Category:Integumentary System - Developmental Pathology]]
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===[[Epitheliogenesis Imperfecta]]===
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===Hypertrichosis===
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*Increased hair growth
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*Both congenital or hereditary
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*In sheep may be caused by [[Flaviviridae#Pestiviruses|Border Disease virus]]
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*Microscopically:
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**Enlarged primary follicles and wool fibres
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*Also accociated with maternal hyperthermia
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[[Category:Integumentary System - Developmental Pathology]]
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===Ichthyosis===
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*Inherited cutaneous disease
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*Occurs in dogs and cattle
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*Grossly:
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**Thickened skin due to [[Skin Glossary - Pathology|hyperkeratosis]]
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**May crack resembling fish scales
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*Increased adherence of keratocytes preventing normal desquamation
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*In cattle occurs in two forms:
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**Ichthiosis fetalis - fatal, stillborn calves or die within days of birth
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**Ichthiosis congenita - folded and thickened skin, fissures and partial [[Skin Glossary - Pathology|alopecia]]
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[[Category:Integumentary System - Developmental Pathology]]
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===Porcine Juvenile Pustular Psoriasiform Dermatitis===
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*Also called '''Pityriasis Rosea'''
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*Occurs in pigs
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*Symmetric lesions on the abdomen, loin and medial thigh
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*Start as small [[Skin Glossary - Pathology|papules]] covered by brown [[Skin Glossary - Pathology|crusts]]
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*-> lesions join and spread -> umbilicated [[Skin Glossary - Pathology|plaques]] containing white centres with erythematous and scaly borders
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*Similar to [[Skin Infectious - Pathology|dermatophytosis]]
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*Histologically:
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**Epidermal hyperplasia, [[Skin Glossary - Pathology|parakeratosis]], epidermal [[Skin Glossary - Pathology|pustules]] and superficial perivascular dermatitis
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*For more detail see [[Porcine Juvenile Pustular Psoriasiform Dermatitis]]
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[[Category:Integumentary System - Developmental Pathology]]
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===Zinc-related disorders===
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*Occurs in Bullterriers and calves
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*Resolves with zinc supplementation in calves but not dogs
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*In dogs:
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**Fatal acrodermatitis
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**Lesions start between digits and on foot pads -> severe interdigital pyoderma -> [[Skin Glossary - Pathology|paronychia]] and [[Skin Glossary - Pathology|hyperkeratosis]] of pads
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**May also occur on pinnae, elbows, muzzle, hocks or become generalised with [[Skin Glossary - Pathology|crusting, ulceration]] and secondary pyoderma
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**Histologically:
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***Hyperkeratosis and bacterial pustular dermatitis
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[[Category:Integumentary System - Developmental Pathology]]

Revision as of 15:27, 21 February 2011

Acanthosis Nigricans

Alopecia and Hypotrichosis

Collagen Dysplasia

Epidermolysis Bullosa

Epidermolysis bullosa in a lamb (Courtesy of Bristol BioMed Image Archive)
  • Also called Red Foot Disease
  • Occurs in sheep, dogs, cattle and horses
  • Development of cutaneous blisters
  • Varies depending on hereditary cause
  • Affected animals tend not to survive
  • Lesions appear at surfaces that are easily damaged, e.g. oral mucosa, feet
  • Microscopically:
    • Epidermal vesicular disease
    • Healing displaces lesions more dorsally
    • May become infected and form pustules


Epitheliogenesis Imperfecta

Hypertrichosis

  • Increased hair growth
  • Both congenital or hereditary
  • In sheep may be caused by Border Disease virus
  • Microscopically:
    • Enlarged primary follicles and wool fibres
  • Also accociated with maternal hyperthermia


Ichthyosis

  • Inherited cutaneous disease
  • Occurs in dogs and cattle
  • Grossly:
  • Increased adherence of keratocytes preventing normal desquamation
  • In cattle occurs in two forms:
    • Ichthiosis fetalis - fatal, stillborn calves or die within days of birth
    • Ichthiosis congenita - folded and thickened skin, fissures and partial alopecia


Porcine Juvenile Pustular Psoriasiform Dermatitis


Zinc-related disorders

  • Occurs in Bullterriers and calves
  • Resolves with zinc supplementation in calves but not dogs
  • In dogs:
    • Fatal acrodermatitis
    • Lesions start between digits and on foot pads -> severe interdigital pyoderma -> paronychia and hyperkeratosis of pads
    • May also occur on pinnae, elbows, muzzle, hocks or become generalised with crusting, ulceration and secondary pyoderma
    • Histologically:
      • Hyperkeratosis and bacterial pustular dermatitis
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