Difference between revisions of "Permethrin Toxicity"
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==Introduction== | ==Introduction== | ||
Permethrin is the active ingredient of many 'spot-on' pesticides used in the control of fleas and ticks in dogs <ref name="multiples"> '''Clinical effects and outcome of feline permethrin spot-on poisonings reported to the Veterinary Poisons information Service (VPIS), London''', ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref>. In is also used in products intended for use in rats, mice, gerbils and guinea pigs <ref name="multiples">'''Clinical effects and outcome of feline permethrin spot-on poisonings reported to the Veterinary Poisons information Service (VPIS), London''', ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref>. Permethrin mediates its effects through modulation of voltage-sensitive sodium channels. <ref name="multiples"> Ray DE (1991)pesticides derived from plants and other organisms. In: Hayes WJ, Laws ER (eds), ''Handbook of Pesticide Toxicity, Classes of Pesticides''referenced in ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf The net result of this modulation is repetitive nerve firing. | Permethrin is the active ingredient of many 'spot-on' pesticides used in the control of fleas and ticks in dogs <ref name="multiples"> '''Clinical effects and outcome of feline permethrin spot-on poisonings reported to the Veterinary Poisons information Service (VPIS), London''', ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref>. In is also used in products intended for use in rats, mice, gerbils and guinea pigs <ref name="multiples">'''Clinical effects and outcome of feline permethrin spot-on poisonings reported to the Veterinary Poisons information Service (VPIS), London''', ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref>. Permethrin mediates its effects through modulation of voltage-sensitive sodium channels. <ref name="multiples"> Ray DE (1991)pesticides derived from plants and other organisms. In: Hayes WJ, Laws ER (eds), ''Handbook of Pesticide Toxicity, Classes of Pesticides''referenced in ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf The net result of this modulation is repetitive nerve firing. | ||
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The spot-on canine preparations are often quite concentrated.<ref name="multiples"> '''BSAVA Manual of Canine and Feline Emergency and Critical Care''', Chapter 19, Second Edition, 2007 </ref>. Cats lack the enzyme glucuronidase transferase <ref name="multiples"> Whittem 1995 Pyrethrin and pyrethroid insecticide intoxication in cats.''Compendium of Continuing Education for the Veterinary Practitioner'' '''17''' 489-492, referenced in ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref> and is therefore unable to utilise the metabolic pathway that dogs and other animals use to break down permethrin into glucuronides and sulphates <ref name="multiples"> Ray DE (1991)pesticides derived from plants and other organisms. In: Hayes WJ, Laws ER (eds), ''Handbook of Pesticide Toxicity, Classes of Pesticides''referenced in ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref> | The spot-on canine preparations are often quite concentrated.<ref name="multiples"> '''BSAVA Manual of Canine and Feline Emergency and Critical Care''', Chapter 19, Second Edition, 2007 </ref>. Cats lack the enzyme glucuronidase transferase <ref name="multiples"> Whittem 1995 Pyrethrin and pyrethroid insecticide intoxication in cats.''Compendium of Continuing Education for the Veterinary Practitioner'' '''17''' 489-492, referenced in ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref> and is therefore unable to utilise the metabolic pathway that dogs and other animals use to break down permethrin into glucuronides and sulphates <ref name="multiples"> Ray DE (1991)pesticides derived from plants and other organisms. In: Hayes WJ, Laws ER (eds), ''Handbook of Pesticide Toxicity, Classes of Pesticides''referenced in ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref> | ||
==Treatment== | ==Treatment== | ||
| − | If permetrin | + | If permetrin toxicily is due to skin contamination immediate removal by washing with lukewarm water containing a gentle detergent such as shampoo or washing-up liquid is indicated <ref name="multiples"> Whittem 1995 Pyrethrin and pyrethroid insecticide intoxication in cats.''Compendium of Continuing Education for the Veterinary Practitioner'' '''17''' 489-492, referenced in ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref>. |
In order to decrease the likelihood of further casualties the affected cat should be isolated from any others in the household. The use of an elizabethan collar will help to prevent ingestion of permethrin through grooming <ref name="multiples"> ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref>. | In order to decrease the likelihood of further casualties the affected cat should be isolated from any others in the household. The use of an elizabethan collar will help to prevent ingestion of permethrin through grooming <ref name="multiples"> ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref>. | ||
Seizures: Diazepam (0.5mg to 1mg per kg by intravenous route)<ref> Valentine 1990, referenced in ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref> | Seizures: Diazepam (0.5mg to 1mg per kg by intravenous route)<ref> Valentine 1990, referenced in ''Journal of Feline Medicine and Surgery''(2007)'''9''',335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 </ref> | ||
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[[Category:Toxicology]] | [[Category:Toxicology]] | ||
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Revision as of 16:02, 24 February 2011
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This article is still under construction. |
Introduction
Permethrin is the active ingredient of many 'spot-on' pesticides used in the control of fleas and ticks in dogs [1]. In is also used in products intended for use in rats, mice, gerbils and guinea pigs [1]. Permethrin mediates its effects through modulation of voltage-sensitive sodium channels. Cite error: Closing </ref> missing for <ref> tag.
Diagnosis
Clinical Signs
Includes: twitching, convulsions, ataxia, hypersalivation, respiratory distress, emesis, diarrhoea, hyperaesthesia, muscle fasciculations, lethargy, tachycardia, anxiety, temporary blindness,death [1], [1].
Laboratory Tests
Pathology
The spot-on canine preparations are often quite concentrated.[1]. Cats lack the enzyme glucuronidase transferase [1] and is therefore unable to utilise the metabolic pathway that dogs and other animals use to break down permethrin into glucuronides and sulphates [1]
Treatment
If permetrin toxicily is due to skin contamination immediate removal by washing with lukewarm water containing a gentle detergent such as shampoo or washing-up liquid is indicated [1]. In order to decrease the likelihood of further casualties the affected cat should be isolated from any others in the household. The use of an elizabethan collar will help to prevent ingestion of permethrin through grooming [1]. Seizures: Diazepam (0.5mg to 1mg per kg by intravenous route)[2] Increased Muscle Activity:
Prognosis
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 Clinical effects and outcome of feline permethrin spot-on poisonings reported to the Veterinary Poisons information Service (VPIS), London, Journal of Feline Medicine and Surgery(2007)9,335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010 Cite error: Invalid
<ref>tag; name "multiples" defined multiple times with different content Cite error: Invalid<ref>tag; name "multiples" defined multiple times with different content Cite error: Invalid<ref>tag; name "multiples" defined multiple times with different content Cite error: Invalid<ref>tag; name "multiples" defined multiple times with different content Cite error: Invalid<ref>tag; name "multiples" defined multiple times with different content Cite error: Invalid<ref>tag; name "multiples" defined multiple times with different content Cite error: Invalid<ref>tag; name "multiples" defined multiple times with different content Cite error: Invalid<ref>tag; name "multiples" defined multiple times with different content - ↑ Valentine 1990, referenced in Journal of Feline Medicine and Surgery(2007)9,335-339 accessed on http://www.fabcats.org/esfm/permethrin.pdf 07.11.2010