Difference between revisions of "Bones Metabolic - Pathology"

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#REDIRECT[[:Category:Bones - Metabolic Pathology]]
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===[[Hypovitaminosis A]]===
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===[[Hypervitaminosis A]]===
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===Hypervitaminosis D===
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*May be of dietary or iatrogenic origin (has narrow safety margin)
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*Key features are hypercalcaemia with metastatic calcification of soft tissues
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*'''Acute poisoning'''
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**In dogs and cats often from rodenticides containing cholecalciferol
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**Grossly:
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***Gastrointestinal haemorrhage
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***Foci of [[Myocardial Mineralisation|myocardial discoloration]]
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**Microscopically:
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***Mucosal haemorrhage
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***Necrosis of crypts
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***Focal myocardial necrosis
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***Mineralisation of intestinal mucosa, [[Arterial Calcification#Medial calcification|blood vessel walls]], [[Pulmonary Calcification|lungs]] and kidneys
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*'''Chronic poisoning'''
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**Grossly:
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***Intense [[Bones - Anatomy & Physiology|osteoclastic activity]] -> active resorption of bone, especially [[Bones - Anatomy & Physiology|trabecular]]
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**Microscopically:
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***Excessive production of [[Bones - Anatomy & Physiology|osteoid]] - appears both eosinophilic and basophilic in different places
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***Marrow cavity may be obliterated
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***Mineralisation of soft tissues, especially [[Arterial Calcification|blood vessel walls]]
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**Due to inhibition of [[Calcium|Parathyroid Hormone (PTH)|PTH]] and increase of [[Calcium#Calcitonin|calcitonin]]
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[[Category:Bones - Metabolic Pathology]]
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[[Category:Toxicology]]
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===Fluorine poisoning===
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*F is widespread in nature
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*Pastures may be contaminated by industrial processes (e.g. brick manufacture)
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*'''Acute poisoning''':
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**Gastroenteritis
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**Nephrosis
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*'''Chronic poisoning''':
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**''Dental abnormalities''
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***Intoxication during teeth development
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***Foci of poor enamel formation - yellow, dark brown/black, chalky
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***Irregular wear of teeth, chip easily
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**''Osteodystrophy = Fluorosis''
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***Generalised skeletal disturbance
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***Most affected are metatarsals and mandibles
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***Periosteal hyperostosis + endosteal bone resorption -> thickened bones with enlarged marrow cavities
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[[Category:Bones - Metabolic Pathology]]
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[[Category:Toxicology]]
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===Lead poisoning===
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*Lead can bind to mineral portion of bone and cartilage
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*In young animals ingesting large dose at once
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** -> Lead induced malfunction of osteoclasts
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** -> Transverse band of increased density on radiographs of metaphysis = "lead line" = [[Retention of Elongated Primary Trabeculae|growth retardation lattice]]
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[[Category:Bones - Metabolic Pathology]]
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[[Category:Toxicology]]
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[[Category:Musculoskeletal System - Pathology]]

Revision as of 18:55, 27 February 2011


Hypovitaminosis A

Hypervitaminosis A

Hypervitaminosis D

  • May be of dietary or iatrogenic origin (has narrow safety margin)
  • Key features are hypercalcaemia with metastatic calcification of soft tissues
  • Acute poisoning
    • In dogs and cats often from rodenticides containing cholecalciferol
    • Grossly:
    • Microscopically:
      • Mucosal haemorrhage
      • Necrosis of crypts
      • Focal myocardial necrosis
      • Mineralisation of intestinal mucosa, blood vessel walls, lungs and kidneys
  • Chronic poisoning

Fluorine poisoning

  • F is widespread in nature
  • Pastures may be contaminated by industrial processes (e.g. brick manufacture)
  • Acute poisoning:
    • Gastroenteritis
    • Nephrosis
  • Chronic poisoning:
    • Dental abnormalities
      • Intoxication during teeth development
      • Foci of poor enamel formation - yellow, dark brown/black, chalky
      • Irregular wear of teeth, chip easily
    • Osteodystrophy = Fluorosis
      • Generalised skeletal disturbance
      • Most affected are metatarsals and mandibles
      • Periosteal hyperostosis + endosteal bone resorption -> thickened bones with enlarged marrow cavities

Lead poisoning

  • Lead can bind to mineral portion of bone and cartilage
  • In young animals ingesting large dose at once
    • -> Lead induced malfunction of osteoclasts
    • -> Transverse band of increased density on radiographs of metaphysis = "lead line" = growth retardation lattice
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