Difference between revisions of "Bones Metabolic - Pathology"

Revision as of 18:55, 27 February 2011

Lead can bind to mineral portion of bone and cartilage
In young animals ingesting large dose at once
- -> Lead induced malfunction of osteoclasts
- -> Transverse band of increased density on radiographs of metaphysis = "lead line" = growth retardation lattice

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 ===[[Hypovitaminosis A]]===
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-===Hypervitaminosis D===
+===[[Hypervitaminosis D]]===
-*May be of dietary or iatrogenic origin (has narrow safety margin)
-*Key features are hypercalcaemia with metastatic calcification of soft tissues
-*'''Acute poisoning'''
-**In dogs and cats often from rodenticides containing cholecalciferol
-**Grossly:
-***Gastrointestinal haemorrhage
-***Foci of [[Myocardial Mineralisation|myocardial discoloration]]
-**Microscopically:
-***Mucosal haemorrhage
-***Necrosis of crypts
-***Focal myocardial necrosis
-***Mineralisation of intestinal mucosa, [[Arterial Calcification#Medial calcification|blood vessel walls]], [[Pulmonary Calcification|lungs]] and kidneys
-*'''Chronic poisoning'''
-**Grossly:
-***Intense [[Bones - Anatomy & Physiology|osteoclastic activity]] -> active resorption of bone, especially [[Bones - Anatomy & Physiology|trabecular]]
-**Microscopically:
-***Excessive production of [[Bones - Anatomy & Physiology|osteoid]] - appears both eosinophilic and basophilic in different places
-***Marrow cavity may be obliterated
-***Mineralisation of soft tissues, especially [[Arterial Calcification|blood vessel walls]]
-**Due to inhibition of [[Calcium|Parathyroid Hormone (PTH)|PTH]] and increase of [[Calcium#Calcitonin|calcitonin]]
-[[Category:Bones - Metabolic Pathology]]
-[[Category:Toxicology]]
 ===Fluorine poisoning===