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Bone Response to Damage (view source)

Revision as of 14:04, 28 September 2007

140 bytes removed ,  14:04, 28 September 2007
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***No cartilage precursor template
 
***No cartilage precursor template
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Physis
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• The cartilage model remains only at the junction of the diaphyseal and epiphyseal centres to become the physis or growth plate.  This is an important site since many congenital or nutritional bone diseases in the growing animal are manifest at this site.
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• In neonates and growing animals, the growth plate is “open”, i.e.  chondrocyte proliferation balances cell maturation and death (Fig 2).  The growth plate “closes” and ossifies at maturity.
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===Physis (Growth plate)===
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*Originates from the cartilage model that remains only at the junction of the diaphyseal and epiphyseal centres
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*Site of many '''congenital''' or '''nutritional''' bone diseases in the growing animal
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*'''Open''' in neonates and growing animals
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**Chondrocyte proliferation balances cell maturation and death
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*'''Closes and ossifies''' at maturity
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===Bone resorption===
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Fig 2. Growth plate cartilage is divided into zones
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Bone resorption
   
• Mediated by two hormones
 
• Mediated by two hormones
 
o Parathyroid hormone (PTH) which is produced by chief cells in the parathyroid glands in response to decreased serum calcium
 
o Parathyroid hormone (PTH) which is produced by chief cells in the parathyroid glands in response to decreased serum calcium
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