Difference between revisions of "Joints Degenerative - Pathology"

Revision as of 15:48, 3 March 2011

Autoantibodies against collagens seen in the joint fluid – no relationship to the disease (ie: not an autoimmune disease) – can be seen in any joint disease

From glucocorticoids injected into joint as antiinflammatories
Injection sometimes causes rapid progression of degeneration
Glucocortyicois suppress anabolic effect of chondrocytes -> reduction of cartilage matrix syhthesis -> proteoglycan depletion -> slower repair

@@ Line 42: / Line 42: @@
-===Spondylosis===
+===[[Spondylosis]]===
-[[Image:Spondylosis.jpg|right|thumb|100px|<small><center>Spondylosis (Image sourced from Bristol Biomed Image Archive with permission)</center></small>]]
-*Often in bulls and dogs, occurs also in horses, cats and pigs
-*[[Musculoskeletal Terminology - Pathology|Osteophyte]] formation on ventral aspect of vertebrae
-**Often around lumbar region
-**Adjacent to intervertebral spaces
-**Varies in size - small spurs -> 'bridges' between vertebrae
-**May extend over few vertebrae
-*Pathogenesis:
-**Repeated abnormal movement between joints -> stress
-** -> Degeneration of [[Joints - Anatomy & Physiology#Fibrocartilagenous joints|''annulus fibrosis'']]
-** -> [[Musculoskeletal Terminology - Pathology|Osteophyte]] formation
-*In dogs usually no symptoms
-*In bulls may cause inability to mount
-*In severe cases repeated damage may progress to recurrent posterior weakness and ataxia in conjuction with fractures of spondylitic and vertebral bone
-[[Category:Joints - Degenerative Pathology]]