Author, Donkey, Bureaucrats, Administrators
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−*Occurs in the dog, mainly smaller breeds
−*Uncommon
−*Progressive erosive polyarthritis
−*Mostly involves elbows, stifles, carpal and tarsal joints
−*Grossly:
−**Marked villus hypertrophy of synovial membrane
−**Cartilage erosion
−**[[Musculoskeletal Terminology - Pathology|Pannus and periarticular osteophyte]] formation
−**In severe cases ankylosis
−*Histologically:
−**Hyperplasia of lining cells
−**Proliferative synovitis
−**Synovial membrane has fibrin deposits
−**Lymphoid and plasma cell infiltration
−**Surrounding haemorrhagic areas
−**Macrophages containing [[Pigmentation - Pathology#Haemosiderin|haemosiderin]]
−**Connective tissue may contain foci of necrosis
−**Areas of erosion of peripheral articular cartilage and underlying subchondral bone
−*Pathogenesis:
−**May involve deposition of immune complexes within joints
−**Substances degrading cartilage are released by synovial cells and macrophages involved in pannus formation
*No causative agent has been found
*No causative agent has been found
*Seem to be immune-mediated diseases
*Seem to be immune-mediated diseases
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===Erosive===
===Erosive===
−====Rheumatoid arthritis====
+====[[Rheumatoid Arthritis]]====
−