|
|
| Line 3: |
Line 3: |
| | *No consensus as to genesis | | *No consensus as to genesis |
| | *Cysts contain mucinous/yellow fluid | | *Cysts contain mucinous/yellow fluid |
| − | | + | *[[More on Ganglion cysts|More about ganglion cysts]] |
| − | | |
| − | More about ganglion cysts: | |
| − | | |
| − | | |
| − | '''[Ganglion cysts in a juvenile dog. Cho K-O et al. Vet Path (2000) 37 340-3]'''
| |
| − | | |
| − | Ganglion cysts:
| |
| − | *Usually in close proximity to joints and tendon sheaths
| |
| − | *Extremely rare in veterinary medicine c.f. humans
| |
| − | *No consensus as to genesis
| |
| − | *Cysts contain mucinous/yellow fluid
| |
| − | *Wall composed of: inner myxomatous and outer
| |
| − | **Inner myxomatous areas
| |
| − | ***Pleomorphic stellate and spindle cells within an abundant myxoid stroma
| |
| − | ***Lined by fibroblasts on the inner aspect (although no true lining cells)
| |
| − | **Outer fibromatous areas
| |
| − | ***Similar to granulation tissue
| |
| − | **Mitoses rare
| |
| − | *The base of all ganglion cysts in contact with the bone, with no boney destruction
| |
| − | *Mucin in the cavities stains blue with acid mucin and with AB-PAS
| |
| − | *EM
| |
| − | **Abundant rough ER and golgi and few mitochondria in the inner myxomatous cells and various stages of myxoid metaplasia
| |
| − | **Cells resemble both synovial cells and fibroblasts
| |
| − | **Small numbers of degenerative ganglion cells in the inner myxomatous lesions – marked dilation of rER and golgi; filopodia, multiple small vacuoles containing a dense granular material in the cytoplasm
| |
| − | **ECM – bundles of collagen fibrils adjacent in the fibroblasts in the initial phase of the mucinous lesions -> collagen fibrils broken and shortened and haphazardly arranged
| |
| − | *No communication with the synovial cavity and no synovial lining so not synovial cysts or adventitious bursa
| |
| − | *Cysts develop within the mucinous lesions surrounding a central collagenous core
| |
| − | *Synovial cells have two appearances on EM:
| |
| − | **Type A cells – phagocytic, contain numerous vacuoles, branched aperiodic fibrils, filopodia, vesicles, mitochondria
| |
| − | **Type B cells – adapted for protein production and contain abundant rER, few mitochondria, occasional vesicles and vacuoles
| |
| − | *Cells in the ganglion walls are similar to type B cells and fibroblasts
| |
| − | *Mucin probably produced by metaplastic fibroblasts
| |
| | | | |
| | [[Category:Joints - Pathology]] | | [[Category:Joints - Pathology]] |