Difference between revisions of "Muscles Developmental - Pathology"

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#REDIRECT[[:Category:Muscles - Developmental Pathology]]
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===[[Myofibrillar Hypoplasia]]===
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===[[Muscle Fibre Hyperplasia]]==
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===[[Muscular Dystrophy]]===
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===Glycogen storage diseases===
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*Caused by a deficiency of an enzyme
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*See [[Glycogen Infiltration|general pathology]]
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*Type II glycogenosis
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**Deficiency of acid maltase
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**In Shorthorn cattle
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**Muscular weakness and incoordination
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**Glycogen stored in skeletal muscle, heart and CNS
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**Type I and II muscle fibres contain glycogen vacuoles
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*Type III glycogenosis
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**Deficiency of debranching enzyme
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**In dogs
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**Causes [[Hypertrophic Cardiomyopathy|hypertrophic cardiomyopathy]] and hepatomegaly
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**Glycogen in skeletal and cardiac muscle, neurons nad hepatocytes
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[[Category:Muscles - Developmental Pathology]]
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===Steatosis===
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*Also called '''lipomatosis'''
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*In cattle, sheep and pigs
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*Fat replaces lost muscle fibres
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*Pale muscle, bilaterally symmetrical
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*No clinical significance
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*Noticed at slaughter or necropsy
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[[Category:Muscles - Developmental Pathology]]
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===Myasthenia gravis (MG)===
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*'''Acquired'''
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**Autoimmune disease
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***Antibodies directed against acetyl choline receptors
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**Associated with [[Thymus neoplasia|thymomas]], [[Megaoesophagus|megaoesophagus]] and dysphagia
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**In adult dogs
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*'''Congenital'''
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**Inherited deficiency in acetyl choline receptors
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**Rare
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**Newfoundland, Jack Russel Terrier, Springer Spaniels – genetic predisposition
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**In dogs – 4 DLA genes recognized: DLA-12, DLA-88, DLA-79 and DLA-64
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**Associated with HLA gene in humans
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**No antibodies against acetyl choline receptors in serum
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**Non-specific muscle [[Muscles Degenerative - Pathology#Atrophy|disuse atrophy]] and fibrosis or no changes on histology
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*Both forms manifest as weakness which worsens on exercise
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[[Category:Muscles - Developmental Pathology]]
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===[[Canine Dermatomyositis]]===
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===[[Muscles Degenerative - Pathology#Porcine stress syndrome|Porcine stress syndrome]]===
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[[Category:Musculoskeletal System - Pathology]]

Revision as of 17:29, 3 March 2011

Myofibrillar Hypoplasia

=Muscle Fibre Hyperplasia

Muscular Dystrophy

Glycogen storage diseases

  • Caused by a deficiency of an enzyme
  • See general pathology
  • Type II glycogenosis
    • Deficiency of acid maltase
    • In Shorthorn cattle
    • Muscular weakness and incoordination
    • Glycogen stored in skeletal muscle, heart and CNS
    • Type I and II muscle fibres contain glycogen vacuoles
  • Type III glycogenosis
    • Deficiency of debranching enzyme
    • In dogs
    • Causes hypertrophic cardiomyopathy and hepatomegaly
    • Glycogen in skeletal and cardiac muscle, neurons nad hepatocytes


Steatosis

  • Also called lipomatosis
  • In cattle, sheep and pigs
  • Fat replaces lost muscle fibres
  • Pale muscle, bilaterally symmetrical
  • No clinical significance
  • Noticed at slaughter or necropsy


Myasthenia gravis (MG)

  • Acquired
    • Autoimmune disease
      • Antibodies directed against acetyl choline receptors
    • Associated with thymomas, megaoesophagus and dysphagia
    • In adult dogs
  • Congenital
    • Inherited deficiency in acetyl choline receptors
    • Rare
    • Newfoundland, Jack Russel Terrier, Springer Spaniels – genetic predisposition
    • In dogs – 4 DLA genes recognized: DLA-12, DLA-88, DLA-79 and DLA-64
    • Associated with HLA gene in humans
    • No antibodies against acetyl choline receptors in serum
    • Non-specific muscle disuse atrophy and fibrosis or no changes on histology
  • Both forms manifest as weakness which worsens on exercise


Canine Dermatomyositis

Porcine stress syndrome

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