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| − | ==Necrosis== | + | ==[[Muscle Necrosis]]== |
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| − | *Necrosis of an entire myofibre is uncommon
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| − | *Segmental necrosis is more typical
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| − | *Muscle cell contents may leak into the blood if the cell membrane is damaged
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| − | *Creatine kinase (CK) is an enzyme which leaks following injury
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| − | **Used to measure the extent of muscle damage
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| − | *Often is followed by [[Muscle Regeneration|regeneration]]
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| − | *Histologically:
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| − | **Hyaline hypercontracted fiber rounded at cross-section and increased diameter and eosin staining
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| − | ***May also be an artifact due to hypercontraction of normal fibres at fixation
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| − | **Fragmenting portions of fibre -> floccular or granular
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| − | **Normal portion of fibre may detach from necrotic part -> retraction caps
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| − | **Infarction may cause '''discoid degeneration''' - necrotic fibres detach at '''Z lines'''
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| − | **May [[Muscles Degenerative - Pathology#Calcification|mineralise]]
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| − | *[[Zenker Degeneration - Pathology|'''Zenker's degeneration''']] - secondary to systemic disease
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| − | **Scattered small segments of necrosis and fast regeneration
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| − | **Sacrolemmal tubes are intact
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| − | [[Category:Muscles - Degenerative Pathology]]
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