Difference between revisions of "CNS Degenerative Diseases - Pathology"

Revision as of 14:11, 8 March 2011

(CDS)

CDS causes signs of senility.
Increasing numbers of dogs and cats are suffering from CDS.
- Prevalence is similar to that seen in humans: an 85 year-old human is roughly equivalent to a 15 year-old cat, and a 13-14 year-old dog.
  - Aging in dogs id breed specific.

@@ Line 3: / Line 3: @@
 ==[[Lysosomal Storage Disease]] ==
-(LSD)
-* Occurs in many breeds of dogs and cats.
-* Genetic defects give deficiencies of specific enzymes of degradation.
-** Disease only occurs in animals homozygous at the gene pair controlling enzyme activity.
-*** The genes are co-dominant.
-** Enzyme activity is extremely low or entirely absent.
-* Large amounts of waste products accumulate within cells.
-** Nervous system cells are predisposed.
-** Cells become engorged.
-** Normal function is prevented.
-* [http://w3.vet.cornell.edu/nst/nst.asp?Fun=Display&imgID=20531 Image 1, courtesy of Cornell Veterinary Medicine] <BR>
-* [http://w3.vet.cornell.edu/nst/nst.asp?Fun=Display&imgID=20530 Image 2, courtesy of Cornell Veterinary Medicine]
-* [http://w3.vet.cornell.edu/nst/nst.asp?Fun=Display&imgID=20185 Image 3, courtesy of Cornell Veterinary Medicine]
-===Clinical Signs===
-* Nervous system cells are predisposed to the disease, and so progressive neurological signs predominate.
-** Develop between 2 weeks and 12 months of age.
-** The disease is ultimately fatal.
-* For example, Siamese cats show:
-** Ganglisidosis
-** Mucopolysaccharidosis
-===Diagnosis===
-* Clinical signs are considered.
-* Urine enzyme assays may be helpful.
-* Post-mortem diagnosis is possible.
-* More recently, gene tests have been available.
-[[Category:Central Nervous System - Degenerative Pathology]]