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**Stain with Giemsa or Wright and examine under oil immersion lens
 
**Stain with Giemsa or Wright and examine under oil immersion lens
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*Present intracellularly in [[Macrophages - WikiBlood|macrophages]] as oval yeast cells with few buds
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*Present intracellularly in [[Macrophages|macrophages]] as oval yeast cells with few buds
 
**Clear halo is seen around the darker staining central material
 
**Clear halo is seen around the darker staining central material
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Image:Histoplasmosis tuberculate chlamydospores.jpg|<center><p>'''Histoplasmosis tuberculate chlamydospores'''</p><sup>Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath</sup></center></gallery>
 
Image:Histoplasmosis tuberculate chlamydospores.jpg|<center><p>'''Histoplasmosis tuberculate chlamydospores'''</p><sup>Copyright Professor Andrew N. Rycroft, BSc, PHD, C. Biol.F.I.Biol., FRCPath</sup></center></gallery>
 
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*Caused by [[Yeast-like fungi|''Histoplasma capsulatum'']]
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*Gross lesions in lungs:
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**Firm encapsulated granulomas ([[Granulomatous Pneumonia|granulomatous pneumonia]])
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*Microscopic lesions:
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**Macrophages with inracytoplasmic yeasts
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*Also in other tissues
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==Test yourself with the Systemic Mycoses Flashcards==
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[[Systemic_Mycoses_-_Flashcards#Histoplasmosis|Histoplasmosis Flashcards]]
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[[Category:Systemic_Mycoses]]
 
[[Category:Systemic_Mycoses]]
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[[Category:To_Do_-_Clinical]]
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[[Category:Respiratory Fungal Infections]]
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