Stomatitis

Introduction

Stomatitis is the inflammation of the mucosa lining any structures within the mouth. This may include the lips, cheeks, tongue and gingiva.

Several different types of stomatitis have been described in the dog: Chronic ulcerative paradental stomatitis which is seen on the buccal mucosa that overlie the teeth, especially in the area of the maxillary canine tooth, fourth premolar and the lateral edge of the tongue. Severe ulceration can occur together with gingival recession.

Ulcerative stomatitis which presents as ulcerations on the margins of the tongue that are common together with a secondary lip-fold dermatitis due to excessive salivation.

Necrotizing stomatitis which is a very painful condition in dogs that may be caused by opportunistic invasion of normal oral flora. Suspected causative organisms include Fusobacterium and spirochaetes. Invasion of these organisms is thought to be associated with reduced host resistance.

Uraemic stomatitis which occurs as a result of uraemia due to renal disease. Severe stomatitis and ulceration of the oral mucosa as well as the margins of the tongue are seen with this condition. The lesions occur due to the bacterial degradation of urea to form ammonia together with dehydration and drying of the oral mucosa that results from renal disease.

Stomatitis in the cat:

Only one form of the disease which is Feline lymphoplasmacytic gingivitis stomatitis complex.

Signalment

Both dogs and cats can develop this condition. Breeds of dog predisposed include the Greyhound, Maltese, Cavalier King Charles, Miniature Schnauzer and Labrador Retriever.

Diagnosis

Clinical Signs

Include severe halitosis, hypersalivation, thick, ropey saliva, anorexia caused by pain, malaise, pyrexia, weight loss and ulceration and bleeding of the gingiva.

Oral Examination

A thorough oral examination under general anaesthesia is often required to aid the diagnosis. Diagnosis is usually made by gross visualisation of the lesions. The mandibular lymph nodes may also be enlarged.

Laboratory Tests

Clinical pathology may be carried out to assess renal function in the case of uraemic stomatitis. Culture and sensitivity tests may be required to aid diagnosis and enable specific treatment.

Biopsy

Often indicated to rule out other diseases such as pemphigus or other immunopathies.

Pathology

Starts as hyperaemia and oedema of the tongue or pharynx with mucoid exudate on the surface. Lymphoid follicles on the soft palate may enlarge and proliferate. Often see white spots due to epithelial hyperplasia and increased mucous secretion, these can be scraped off to leave ordinary mucosa underneath.

Treatment

Treatment is both symptomatic to control the clinical signs as well as specific to the cause of the condition. The underlying cause should be sought and treated appropriately.

Thorough teeth cleaning is necessary as well as systemic antibiotics (effective against aeobes and anaerobes). Oral rinses such as chlorhexidine may also be useful. Corticosteriods have been suggested with cases of chronic ulcerative paradental stomatitis. Diet modification in cases of renal disease to reduce blood urea levels. Tooth extraction in the most severely affected area has been suggested. Resistent lesions in cats have been shown to respond to bovine lactoferrin in some cases.

Prognosis

Depends on the underlying cause.

Literature Search

Use these links to find recent scientific publications via CAB Abstracts (log in required unless accessing from a subscribing organisation).


Stomatitis publications

Stomatitis in dogs publications

Stomatitis in cats publications

Stomatitis in horses publications

Stomatitis in cattle publications

Stomatitis in sheep publications

Stomatitis in pigs publications

References

Merck & Co (2008) The Merck Veterinary Manual

Nelson, R.W. and Couto, C.G. (2009) Small Animal Internal Medicine (Fourth Edition) Mosby Elsevier

Tutt, C., Deeprose, J. and Crossley, D. (2007) BSAVA Manual of Canine and Feline Dentistry (3rd Edition) BSAVA