|
|
| (11 intermediate revisions by 4 users not shown) |
| Line 1: |
Line 1: |
| − | {{OpenPagesTop}}
| + | <big><center>[[Joints - degenerative#Disc protrusion|'''BACK TO DISC PROTRUSION''']]</center></big> |
| − | Also Known As: '''''IVDD''''' — '''''Hansen Type I IVDD''''' — '''''Hansen Type II IVDD''''' — '''''Fibrocartilagenous Embolic Myelopathy''''' — '''''FCE''''' — '''''Explosive Disc'''''
| |
| | | | |
| − | ==Introduction==
| |
| − | [[File:Intervertebral disc degeneration.jpg|200px|right|thumb|Intervertebral disc degeneration (Courtesy of Bristol Biomed Image Archive)]]
| |
| − | The term ''''Intervertebral Disc Disease'''' ('''IVDD''') refers to several pathological processes involving the intervertebral discs. It is common in the '''dog''', and certain breeds of dog have a genetic predisposition to early-onset IVDD. Any disc in the [[Spinal Column - Anatomy & Physiology|spinal column]] may be affected with the most prevalent clinical signs resulting from lesions in the '''cervical, thoracic or lumbar discs'''.
| |
| | | | |
| − | ==Hansen Type I==
| + | <big>'''Intervertebral disk degeneration'''</big> |
| − | | + | *Associated with loss of water from the nucleus pulposus due to lowering of proteoglycan content |
| − | In '''[[Chondrodysplasia|chondrodystrophic breeds]]''' such as the '''dachshund''' and the '''bassett hound''', the [[Spinal Column - Anatomy & Physiology|nucleus pulposus]] undergoes '''chondroid degeneration'''. These breeds are genetically predisposed to such pathology and changes such as '''[[Mineralisation - Pathology|mineralisation]]''' are normally apparent in more than one disc by the time the dog is one year old. The abnormal disc may bulge, chronically impinging on the ventral cord and producing slow onset of clinical signs. However dorsal '''extrusion''' of the degenerate nucleus pulposus - which ruptures through the annulus fibrosis into the spinal canal - can occur at any point, causing '''acute''' [[Spinal Cord - Anatomy & Physiology|spinal cord]] '''trauma'''. The initial impact of the nucleus causes '''contusion''' of the spinal cord, and the extruded nucleus continues to '''compress''' the cord. This is known as '''Type I (Hansen) IVDD'''.
| + | **Reduces the cushioning function |
| − | | + | **Can lead to herniation of the nucleus pulposus through the annular rings and impinge on the spinal cord. |
| − | Type I IVDD most commonly occurs in '''small and [[Chondrodysplasia|chondrodystrophic breeds]]''', but it can occur in any dog. It is most likely to occur in '''young to middle-aged''' dogs. Clinical signs are '''acute''' in onset. Neurolocalisation will depend on which disc is affected but the classic signs are a T3-L3 myelopathy (the most common localisation) are '''a non-ambulatory pelvic limb para-paresis and poor paw placement (proprioception)'''. Withdrawal reflexes may be absent or abnormal, deep pain perception may be absent, and patellar reflexes may be absent or abnormal (e.g. crossed extensor reflex) dependent on the location and severity of the lesion.
| + | *Breeds |
| − | | + | **Dachshund (45-75% of cases), Pekingese, beagle, Lhaso apso and cocker spaniel |
| − | * '''Cervical discs''' - neck pain is the most common clinical sign, paresis is less common as there is more space in the vertebral canal at this point, so compression is less severe. | + | **Probably partly because all are chondrodysplastic to a varying degree |
| − | | + | ***Occurs in all disks simultaneously (cf: non chondrodysplastic dogs – degeneration in only one disk at a time). |
| − | * '''Thoracolumbar discs''' - pelvic limb paresis and ataxia are the most common clinical signs. | + | ***Chondrodysplastic dogs -> chondroid metaplasia of the nucleus pulposus, with progressive calcification |
| − | | + | ***Occurs at a young age … cf non-chondrodysplastic breeds , occurs as a senile change |
| − | * '''Lumbosacral discs''' - pelvic limb lameness, spinal pain and urinary incontinence are the most common clinical signs. | + | ***Progressive decrease in amount of glycosaminoglycans, and changes from chondroitin sulphate to keratin sulphate over the first few years of life |
| − | | + | ***Hansen type I protrusions – explosive and large |
| − | ==Hansen Type II ==
| + | **Non-chondrodysplastic dogs -> progressive fibrous metaplasia of the nucleaus pulposus, starting at the periphery |
| − | '''Type II IVDD''' is more common in '''older, large breed dogs''' such as the German Shepard Dog. IVDD type II involves '''fibroid degeneration of the [[Spinal Column - Anatomy & Physiology|nucleus pulposus]]''' and '''protrusion of the [[Spinal Column - Anatomy & Physiology|annulus fibrosis]]'''. Over time the fibroid tissue in the disc is replaced by '''collagenous tissue'''. At the same time, '''hypertrophy''' of the surrounding '''annulus''' occurs, causing '''progressive compression of the spinal cord'''. Mineralisation of the discs is rare.
| + | ***Increased amount of type I collagen (poor at withstanding compressive loads) |
| − | | + | ***Can lead with time, to bulging of the remaining nucleus pulposus dorsally, as it becomes increasingly constricted by the annular fibrosa |
| − | Clinical signs are normally '''insidious''' but the dog may present acutely. It is common for the dog to only show signs of '''dynamic compression''' of the spinal cord, for example when jumping. As the onset of disease is normally '''gradual''' and '''progressive''', so clinical signs are normally less severe on presentation. These include:
| + | ***Calcification is uncommon |
| − | | + | ***Hansen type II protrusions -> small and progressive |
| − | * Yelping (unprovoked or when handled) | |
| − | * Reluctance to jump or climb | |
| − | * Low head carriage and arched back | |
| − | * Reluctance to move head and neck | |
| − | * Restlessness and panting | |
| − | | |
| − | ==Fibrocartilagenous Embolic Myelopathy (FCE)==
| |
| − | This '''vascular''' disease is typically seen in '''young medium to large breed dogs''' but it can occur in any dog or cat. It occurs when a '''[[Embolism|fibrocartilagenous embolus]]''' causes an '''[[Infarction|infarction]] of the [[Spinal Cord - Anatomy & Physiology|spinal cord]] parenchyma'''.
| |
| − | | |
| − | It is typically '''peracute''' in onset and clinical signs are '''non-progressive''', with a classic history of a dog jumping for a toy, yelping, and collapsing with paresis. The disease is '''non-painful''' as no pain receptors are present in the spinal cord '''parenchyma'''.
| |
| − | | |
| − | =='Explosive Disc'==
| |
| − | Explosive disc is the '''low volume, high velocity traumatic extrusion of the normal nucleus pulposus'''. This causes a '''non-compressive contusion injury to the spinal cord'''. The signalment, clinical signs and history are normally similar to FCE, with the dog presenting with a non-progressive paresis of peracute onset.
| |
| − | | |
| − | ==Diagnosis==
| |
| − | | |
| − | A thorough '''history, clinical exam and neurological exam''' should be performed on presentation. The [[Neurological Examination - Dog & Cat|neurological exam]] should reveal the '''severity and neuro-localisation''' of the disease. Motor function, proprioception, spinal reflex arcs, the location of spinal pain and most importantly the presence or absence of conscious pain perception can provide an overall picture of location and severity.
| |
| − | | |
| − | Once this has been achieved imaging modalities can be used to further localise and classify the lesion.
| |
| − | | |
| − | ===Radiography===
| |
| − | Survey radiographs should be taken to identify any signs of intervertebral disc disease. These signs include:
| |
| − | * '''A narrowing of the intervertebral disc space''' | |
| − | * '''Small or opaque intervertebral foramen''' | |
| − | * '''The presence of gas in the intervertebral foramen''' | |
| − | * '''Calcificiation of disc material overlying the vertebral canal''' | |
| − | * '''Presence of disc material in the spinal canal''' | |
| − | | |
| − | Radiographs are normally taken when the animal in '''anaesthetised''' to allow appropriate positioning. '''Lateral and ventrodorsal views''' should be taken. Should these radiographs fail to demonstrate the full extent of the lesion, a '''[[Cerebral Spinal Fluid - Anatomy & Physiology|CSF]] sample''' should be taken to provide more information.
| |
| − | | |
| − | ===Myelography===
| |
| − | Myelography involves injection of '''non-ionic contrast medium''' into the '''subarachnoid space''', which '''outlines the spinal cord'''. It should be performed in all cases which showed no clear signs on survey radiographs, cases where the survey radiographs do not match the clinical signs, cases where the extent of the lesion is unknown and any potentially surgical cases. The procedure should be performed under general anaesthesia - often the animal will be moved directly to theatre following myelography. Myelography can identify the lesion and confirm IVDD:
| |
| − | | |
| − | '''1) Extradural''' - The contrast medium bulges towards the cord - this is the sign you would expect to see in Type I and II IVDD.
| |
| − | | |
| − | '''2) Intramedullary''' - The contrast lines are further pushed apart by an intramedullary lesion. This pattern is seen with FCE. Common differentials are neoplasia and spinal cord oedema.
| |
| − | | |
| − | '''3) Intradural-extramedullary''' - The contrast medium surrounds the lesion in these cases, producing a fork-shape in the contrast line. This is most commonly caused by a nerve root tumour.
| |
| − | | |
| − | ===MRI===
| |
| − | MRI is the '''gold-standard''' for identifying IVDD, however it is generally only available in '''referral hospitals''' and is very expensive.
| |
| − | | |
| − | ==Treatment==
| |
| − | With '''Type I IVDD''' you may consider '''immediate referral'''. Providing there are no cost constraints, performing '''prompt surgery''' to relieve the pressure on the spinal cord results in an '''improved prognosis''' and specialist referral units are equipped to do this. '''Conservative treatment''' may be considered if signs are '''mild''' (presence of mild pain) and '''non-progressive''', if performing surgery is against the owners wishes or there are significant '''cost constraints'''. '''Type II IVDD''' is treated in the same way as type I but as clinical signs are less acute, a rapid decision about the choice of treatment is rarely necessary.
| |
| − | | |
| − | ===Surgery===
| |
| − | The surgical procedure performed depends on the location of the lesion. The procedure performed on a '''thoracolumbar lesion''' is a '''hemilaminectomy'''. A '''ventral slot''' is performed on '''cervical lesions'''. Generally a fenestration is made in the vertebral canal and the extruded disc material is cooped out to relieve pressure on the spinal cord. Prophylactic laminectomies may be performed on unaffected discs to prevent recurrence.
| |
| − | | |
| − | Post-operatively, it is essential that the dog is placed on a program of '''strict cage rest and physiotherapy''' for a minimum of '''6 weeks'''. [[NSAIDs]] may also be given.
| |
| − | | |
| − | ===Conservative Treatment===
| |
| − | The aims of conservative treatment are to:
| |
| − | :allow the '''extruded disc material time to dissipate''', relieving pressure on the spinal cord
| |
| − | :allow the '''dorsal annulus to heal''', preventing further extrusion of disc material.
| |
| − | This involves '''strict cage rest for a minimum of 6 weeks''', very short '''lead walk''' and '''physiotherapy'''. NSAIDs may also be given.
| |
| − | | |
| − | FCE and 'explosive disc' are non-progressive and the appropriate treatment is '''supportive care''' (management of the recumbent animal), '''time''' and '''physiotherapy'''.
| |
| − | | |
| − | Steroid treatment is now contraindicated in acute spinal trauma.
| |
| − | | |
| − | ==Prognosis==
| |
| − | Prognosis for IVDD type I depends on the '''severity and duration of clinical signs and the treatment options'''. If '''[[Sensory Pathways - Anatomy & Physiology|deep pain''' sensation]] is present and surgery is performed immediately then prognosis is good. Prognosis worsens the longer deep pain is absent - prognosis is grave with a loss of deep pain longer than 48 hours.
| |
| − | | |
| − | Type II IVDD prognosis depends on the '''severity of the presenting signs''', but as there is a more chronic loss of function recovery is '''slower''' and some functional deficits may never be regained.
| |
| − | | |
| − | Prognosis for FCE and explosive disc can be judged on the level of '''deep pain sensation and [[Peripheral Nervous System Pathology Overview|LMN function]]'''. Although clinical signs may look bad (especially to the owners), dogs with appropriate deep pain sensation have the ability to make an impressive recovery.
| |
| − | | |
| − | {{Learning
| |
| − | |flashcards = [[Small Animal Emergency and Critical Care Medicine Q&A 16]]
| |
| − | }}
| |
| − | | |
| − | ==References==
| |
| − | Kirby, R (1998) '''Self-Assessment Colour Review - Small Animal Emergency & Critical Care Medicine''' ''Manson''
| |
| − | | |
| − | McKee, M (2000) '''Intervertebral disc disease in the dog 1. Pathophysiology and diagnosis''' ''In Practice 2000 22: 355-36''
| |
| − | | |
| − | McKee, M (2000) '''Intervertebral disc disease in the dog 2. Management options''' ''In Practice 2000 22: 458-47''
| |
| − | | |
| − | RVC staff (2009) '''Nervous System and Special Senses''' RVC Integrated BVetMed Course, ''Royal Veterinary College''
| |
| − | | |
| − | | |
| − | {{review}}
| |
| − | | |
| − | {{OpenPages}}
| |
| − | | |
| − | [[Category:Joints - Degenerative Pathology]]
| |
| − | [[Category:Neurological Diseases - Dog]]
| |
| − | [[Category:Expert Review - Small Animal]]
| |