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| − | {{Podcasts
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| − | |link = http://media.bloomsburymediacloud.org/podcasts/wikivet-english/porcine-epidemic-diarrhoea
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| − | Also Known As: '''''Coronaviral Encephalomyelitis — Coronaviral Enteritis — Epidemic Viral Diarrhoea — Ontario Encephalitis — PED — EVD — TOO (The Other One)'''''
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| − | Caused By: '''''Porcine Epidemic Diarrhoea Virus — PEDV — CV777'''''
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| − | ==Introduction==
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| − | Porcine Epidemic Diarrhoea (PED) is a '''gastrointestinal disease''' of pigs caused by a '''[[Coronaviridae|coronavirus]].'''
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| − | PED is very similar to the coronavirus that causes '''[[Transmissible Gastroenteritis Virus]] (TGE)''', also in pigs.
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| − | ==Distribution==
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| − | Worldwide. Transmission is purely '''faecal-oral.'''
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| − | ==Signalment==
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| − | Disease is most severe in '''neonatal pigs''' as they are more susceptible to dehydration.
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| − | Outbreaks have also been seen in fattening pigs and adults, often associated with '''moving and/or mixing of groups'''. Outbreaks may be recurrent over a period of several weeks.
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| − | ==Clinical Signs==
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| − | Generally, mortality is very low and the disease is mild.
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| − | '''Gastrointestinal''' disease presents with '''watery [[Diarrhoea|diarrhoea]], vomiting/regurgitation and anorexia'''. In more severe cases there may be pyrexia, mild dehydration and signs of abdominal pain.
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| − | In some cases '''mortality''' in neonatal pigs is increased and may reach up to '''50% in pigs <1 week of age''', but it is generally not as high as with [[Transmissible Gastroenteritis Virus|TGE]].
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| − | ==Diagnosis==
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| − | PED can be demonstrated by '''[[Immunofluorescence]] (IF) or Immunohistochemistry (IHC)''' applied to sections of small intestines from pigs '''euthanased less than 1 day after the onset of diarrhoea.''' This is the most sensitive, reliable and rapid method of achieving definitive diagnosis.
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| − | PED '''antigen''' can be detected via '''[[ELISA testing|ELISA]]''' from '''faeces'''. This is useful for group disease screening.
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| − | PED '''antibodies''' can be detected serologically via '''IF and ELISA'''. High titres may persist for up to one year after infection.
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| − | On '''post-mortem, the small intestine is filled with yellow fluid''' and distended.
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| − | Microscopically, '''exfoliation of enterocytes and villous stunting''' can be seen in the small intestine from 24h after infection. These changes are similar but less severe than those seen with TGE. The incubation period of PEDV is also longer than TGE: 22-36h compared to 18-24h.
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| − | ==Treatment==
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| − | Treatment is supportive by providing '''free access to water'''. '''Electrolyte solutions and energy supplements''' are recommended in piglets. '''Withholding feed''' is advisable in fattening swine.
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| − | ==Control==
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| − | '''Biosecurity''' can prevent introduction of virus to farms by animal and human traffic.
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| − | '''Deliberate transmission''' of PED by spreading virus contaminated faeces in with pregnant sows has been used to '''stimulate lactogenic immunity''' and shorten the disease on the farm by protecting neonatal stock. This can be a dangerous practice if sows are within 14 days of farrowing as abortions may occur. The diagnosis must be confirmed before this is attempted.
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| − | When several consecutive litters are affected, movement onto the farm should be stopped and all pigs born within a four week period should be relocated to a different site.
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| − | PED is not deemed of enough economical importance to require a vaccine.
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| − | {{Learning
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| − | |flashcards = [[Porcine Epidemic Diarrhoea Flashcards]]
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| − | }}
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| − | ==References==
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| − | <references/>
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| − | {{CABI source
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| − | |datasheet = [http://www.cabi.org/ahpc/?compid=3&dsid=68594&loadmodule=datasheet&page=2144&site=160 porcine epidemic diarrhoea] and [http://www.cabi.org/ahpc/?compid=3&dsid=68586&loadmodule=datasheet&page=2144&site=160 porcine epidemic diarrhoea virus]
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| − | |date =19 June 2011
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| − | <br><br>
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| − | {{Mandy Nevel
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| − | |date = 09 September 2011
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| − | {{OpenPages}}
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| − | [[Category:Coronaviridae]]
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| − | [[Category:Pig Viruses]]
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| − | [[Category:Intestinal Diseases - Pig]][[Category:Neurological Diseases - Pig]]
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| − | [[Category:CABI Expert Review Completed]][[Category:CABI AHPC Pages]]
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