Changes

'''Piglets and Weaners:'''

'''Piglets and Weaners:'''

Piglet and weaners suffer from prostration, hind limb '''stiffness''', generalised weakness, muscle fasciculation’s, retarded growth, depression, excitation, head pressing, circling, '''hyperaesthesia''', abnormal behaviour/'''aggression''' and '''coma'''. In piglets the disease also causes '''changes in hair coat''' (dull/rough), '''ocular erosions''', '''enlarged distended bladder''' and  '''constipation/reduction in faces or diarrhoea'''.

Piglet and weaners suffer from prostration, hind limb '''stiffness''', generalised weakness, muscle fasciculation’s, retarded growth, depression, excitation, head pressing, circling, '''hyperaesthesia''', abnormal behaviour/'''aggression''' and '''coma'''. In piglets the disease also causes '''changes in hair coat''' (dull/rough), '''ocular erosions''', '''enlarged distended bladder''' and  '''constipation/reduction in faces or diarrhoea'''.

'''Sows'''

'''Sows:'''

 

In sows the disease causes '''infertility''', reproductive failures, '''embryonic mortality''' and '''return to oestrus in the first third of gestation''' and '''stillbirths, small litters''' and '''mummification in late gestation'''.  

In sows the disease causes '''infertility''', reproductive failures, '''embryonic mortality''' and '''return to oestrus in the first third of gestation''' and '''stillbirths, small litters''' and '''mummification in late gestation'''.  

'''Boar'''

'''Boars:'''

 

In the boar it causes male '''infertility, lack of libido, haemospermia''', and '''orchitis with epidydimitis''' and swelling of the genitals.

In the boar it causes male '''infertility, lack of libido, haemospermia''', and '''orchitis with epidydimitis''' and swelling of the genitals.

==Epidemiology==

==Epidemiology==

The disease is '''self limited''' and closed herds will have sporadic outbreaks of the disease once a herd is infected. The virus can be found in the '''axon of neurons''' from its original site of replication, which is thought to be the '''nasal mucosa and tonsils'''.  It is also found  in tissues such as lung, liver, spleen, kidney, lymph node, heart and testis; suggesting that the virus is spread hematogenously.

The disease is '''self limiting''' and closed herds will have sporadic outbreaks of the disease once a herd is infected. The virus can be found in the '''axon of neurons''' from its original site of replication, which is thought to be the '''nasal mucosa and tonsils'''.  It is also found  in tissues such as lung, liver, spleen, kidney, lymph node, heart and testis; suggesting that the virus is spread hematogenously.

==Distribution==

==Distribution==

''Blue-eyed disease'' can be diagnosed by a combination of history, above clinical signs, serology, lesions and virus isolation.

''Blue-eyed disease'' can be diagnosed by a combination of history, above clinical signs, serology, lesions and virus isolation.

A week after infection a serological response can be seen using a '''virus neutralization test''' and 2 weeks later with a '''haemagglutination inhibition test'''.  

A week after infection a serological response can be seen using a '''virus neutralization test''' and 2 weeks later with a '''haematoglutination inhibition test'''.  

The diagnosis can be '''confirmed''' using '''virus isolation''' on PK15 or primary pig kidney, using samples from infected tonsils, brain or lung.

The diagnosis can be '''confirmed''' using '''virus isolation''' on PK15 or primary pig kidney, using samples from infected tonsils, brain or lung.