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|q1=What is a prion (PrP)?
|q1=What is a prion (PrP)?
|a1=
|a1=
A prion (PrP) is a protein that occurs normally in the nervous and lymphoreticular tissues. When is changes conformation (PrP<sup>sc</sup>/PrP<sup>Res</sup>) it becomes an infectious agent and causes degeneration of neurological tissue.
A prion (PrP) is a protein that occurs normally in the nervous and lymphoreticular tissues. When it changes conformation (PrP<sup>sc</sup>/PrP<sup>Res</sup>) it becomes an infectious agent and causes degeneration of neurological tissue.
|l1=Scrapie#Introduction
|l1=Scrapie#Introduction
|q2=What species are affected by scrapie?
|q2=What species are affected by scrapie?
|q5=What age does scrapie normally affect sheep?
|q5=What age does scrapie normally affect sheep?
|a5=
|a5=
3-4 years old
3-5 years old
|l5=Scrapie#Signalment
|l5=Scrapie#Signalment
|q6=What is the pathogenesis of scrapie?
|q6=What is the pathogenesis of scrapie?
*Bruxism, fine tremors, and hyperaesthesia to sound or sudden movements
*Bruxism, fine tremors, and hyperaesthesia to sound or sudden movements
*Exercise intolerant and develop progressive ataxia (difficulty in turning, swaying on their hind hindquarters and have gait abnormalities such as a high stepping gait in the forelimbs or a bunny hopping gait in the hind limbs)
*Exercise intolerant and develop progressive ataxia (difficulty in turning, swaying on their hind hindquarters and have gait abnormalities such as a high stepping gait in the forelimbs or a bunny hopping gait in the hind limbs)
*Intense pruritis ( compulsive rubbing, nibbling at the skin, or scraping against fixed objects)
*Intense pruritus ( compulsive rubbing, nibbling at the skin, or scraping against fixed objects)
*Wool loss is typically seen over the hindquarters and lateral thorax
*Wool loss is typically seen over the hindquarters and lateral thorax
*Lip smacking or nibbling reflex can often be elicited by scratching over the lumbar region, which is characteristic of scrapie.
*Lip smacking or nibbling reflex can often be elicited by scratching over the lumbar region, which is characteristic of scrapie.
|q9=What are the differential diagnosis for scrapie in sheep?
|q9=What are the differential diagnosis for scrapie in sheep?
|a9=
|a9=
*Viral encephalomyelitides (pseudorabies or Aujeszky’s disease
*Pseudorabies or Aujeszky’s disease
*Rabies
*Rabies
*Maedi visna
*Maedi visna
[[Category:CABI Flashcards]]
[[Category:CABI Flashcards]]
[[Category:To_Do_-_CABI review]]
[[Category:Sheep Flashcards]]
[[Category:Neurological Diseases Flashcards]] [[Category:Integumentary Diseases Flashcards]]