Difference between revisions of "Vesicular Stomatitis Virus"

From WikiVet English
Jump to navigation Jump to search
(9 intermediate revisions by one other user not shown)
Line 1: Line 1:
{{OpenPagesTop}}
+
Also Known As '''''VS'''''
Also Known As: '''''VS VSV Alagoas Virus Brazil Virus Cocal Virus Piry Virus Chandipura Virus Isfahan Virus'''''
+
 
 +
Caused By – ''Vesicular Stomatitis Virus – VSV Alagoas Virus Brazil Virus Cocal Virus Piry Virus Chandipura Virus Isfahan Virus''
  
 
==Introduction==
 
==Introduction==
Vesicular Stomatitis is an '''oral disease''' of '''cattle, horses, pigs and people''',  caused by a [[Rhabdoviridae |rhabdovirus]], of which there are two distinct serotypes: VSV-New Jersey (VS-NJ) and VSV-Indiana (VS-IN). Although antibodies have been found in many species of mammal and bird, no clinical signs appear to develop.
+
[[File:VS Cow.jpg|thumb|200px|right|Vesicular Stomatitis oral lesion in a cow. Copyright CFSPH Iowa State.]]
 +
[[File:VS Horse.jpg|thumb|200px|right|Vesicular Stomatitis oral lesion in a horse]]
 +
[[File:VS Foot.jpg|thumb|200px|right|Vesicular Stomatitis coronary band lesion]]
 +
Vesicular Stomatitis is an '''oral disease''' of '''cattle, horses, pigs and people''',  caused by a [[Rhabdoviridae | rhabdovirus]], of which there are two distinct serotypes: VSV-New Jersey (VS-NJ) and VSV-Indiana (VS-IN). Although antibodies have been found in many species of mammal and bird, no clinical signs appear to develop.
  
 
The main importance of VS is its '''identical presentation to [[Foot and Mouth Disease]]''', in fact they cannot be clinically differentiated.
 
The main importance of VS is its '''identical presentation to [[Foot and Mouth Disease]]''', in fact they cannot be clinically differentiated.
Line 9: Line 13:
 
VS is '''zoonotic''' and can cause acute flu-like disease in humans.
 
VS is '''zoonotic''' and can cause acute flu-like disease in humans.
  
This disease is '''notifiable''' to the World Organisation for Animal Health [http://www.oie.int/ (OIE)].
+
This disease is '''notifiable''' to the World Organisation for Animal Health [http://www.oie.int/ (OIE)]
  
 
==Distribution==
 
==Distribution==
VS is present exclusively in the Western hemisphere, mainly in the '''Americas''', including parts of the Caribbean and South America. It is transmitted by a range of insect vectors including the [[Musca spp. |house fly]] and [[Ceratopogonidae |''Culicoides'' midge]]. The virus can also be transmitted via '''direct contact''' with lesions, saliva and fomites.
+
VS is present exclusively in the Western hemisphere, mainly in the '''Americas''', including parts of the Caribbean and South America.
 +
 
 +
VS is transmitted by a range of insect vectors including the [[Musca spp. | house fly]] and [[Ceratopogonidae | Culicoides midge]].
 +
 
 +
The virus can also be transmitted via '''direct contact''' with lesions, saliva and fomites.
  
 
==Signalment==
 
==Signalment==
Line 21: Line 29:
 
==Clinical Signs==
 
==Clinical Signs==
 
VS is characterised by its appearance – beginning as '''blanched macules''' and developing into  '''vesicular lesions''' on the '''tongue, oral and nasal mucosa, mammary glands, external genitalia and coronary band'''. When the vesicles rupture after 24-48h, '''erosions and excoriations''' remain in the affected mucosa.  
 
VS is characterised by its appearance – beginning as '''blanched macules''' and developing into  '''vesicular lesions''' on the '''tongue, oral and nasal mucosa, mammary glands, external genitalia and coronary band'''. When the vesicles rupture after 24-48h, '''erosions and excoriations''' remain in the affected mucosa.  
 
+
'''Hypersalivation''' often also occurs.  
'''Hypersalivation''' often also occurs. Coronary band lesions cause '''lameness and defective horn growth'''.
+
Coronary band lesions cause '''lameness and defective horn growth'''.
  
 
Other clinical manifestations include '''depression, weight loss, low productivity, agalactia and mastitis.''' Animals with genital lesions may be reluctant to breed.
 
Other clinical manifestations include '''depression, weight loss, low productivity, agalactia and mastitis.''' Animals with genital lesions may be reluctant to breed.
Line 28: Line 36:
 
Affected animals are often '''pyrexic, anorexic and dysphagic''' due to reduced food intake and interference of lesions with prehension/pain when eating.
 
Affected animals are often '''pyrexic, anorexic and dysphagic''' due to reduced food intake and interference of lesions with prehension/pain when eating.
  
Shedding ceases 6-7 days post-infection <ref> Katz, J. B., Eernisse, K. A., Landgraf, J. G., Schmitt, B. J. (1997) '''Comparative performance of four serodiagnostic procedures for detecting bovine and equine vesicular stomatitis virus antibodies.''' ''J Vet Diagnostic Investigation'', 9(3):329-331; 5</ref> and '''lesions resolve within 14 days.''' Once '''recovered''', animals do not maintain infection or shed the virus.
+
Shedding ceases 6-7 days post-infection <ref> Katz, J. B., Eernisse, K. A., Landgraf, J. G., Schmitt, B. J. (1997) '''Comparative performance of four serodiagnostic procedures for detecting bovine and equine vesicular stomatitis virus antibodies.''' J Vet Diagnostic Investigation, 9(3):329-331; 5</ref> and '''lesions resolve within 14 days.'''
 +
 
 +
Once '''recovered''', animals do not maintain infection or shed the virus.
  
 
Deaths from VS are rare and usually due to secondary complications.
 
Deaths from VS are rare and usually due to secondary complications.
  
 
==Diagnosis==
 
==Diagnosis==
Definitive diagnosis requires laboratory testing. '''Virus isolation''' can be attempted from nasal/oral swabs, epithelial tags, skin scrapings or biopsies. Only active lesions will contain infective virus particles. PCR is potentially more sensitive but not widely used.
+
Definitive diagnosis requires laboratory testing.
 +
'''Virus isolation''' can be attempted from nasal/oral swabs, epithelial tags, skin scrapings or biopsies. Only active lesions will contain infective virus particles.
 +
PCR is potentially more sensitive but not widely used.
  
Serological tests are routinely used and will also differentiate serotypes. '''Competitive [[ELISA testing |ELISA (cELISA)]]''' is used as a screening test and '''Serum Neutralisation (SN) and [[Complement Fixation]] (CF)''' are also commonly used to diagnose VS. Tests that detect IgG such as the cELISA and SN may remain positive for up to 3 years after infection. CF is more indicative of '''recent infection''', especially when rising titres are present.
+
Serlogical tests are routinely used and will also differentiate serotype.
 +
'''Competitive [[ELISA testing | ELISA (cELISA)]]''' is used as a screening test and '''Serum Neutralisation (SN) and Complement Fixation (CF)''' are also commonly used to diagnose VS.
 +
Tests that detect IgG such as the cELISA and SN may remain positive for up to 3 years after infection.
  
On '''histopathology''', intercellular oedema is present in the Malphigian cell layer and epithelial cell necrosis is evident. The necrotic cells are strongly eosinophilic and nuclei are pyknotic. Basal cells are separated by vesicular fluid. Other non-specific inflammatory changes are usually also present.
+
CF is more indicative of '''recent infection''', especially when rising titres are present.
 +
 
 +
On '''histopathology''', intercellular oedema is present in the Malphigian cell layer and epithelial cell necrosis is evident. The necrotic cells are strongly eosinophilic and nuclei are pyknotic.  
 +
Basal cells are separated by vesicular fluid.  
 +
Other non-specific inflammatory changes are usually also present.
  
 
==Treatment==
 
==Treatment==
The disease is '''self-limiting''' and usually requires no treatment. Secondary bacterial infection can delay healing of lesions and usually respond to antibiotics. Symptomatic care may be indicated in severe cases.
+
Disease is '''self-limiting''' and usually requires no treatment.
 +
Secondary bacterial infection can delay healing of lesions and usually respond to antibiotics.  
 +
Symptomatic care may be indicated in severe cases.
  
 
==Control==
 
==Control==
Several [[vaccines]] are being developed or used experimentally but none are commercially available in the USA.
+
Several vaccines are being developed or used experimentally but none are commercially available in the USA.
  
 
Appropriate biosecurity, disinfection protocols, temporary isolation of infected animals/groups and limiting exposure to insect vectors may help to reduce the scale of outbreaks.
 
Appropriate biosecurity, disinfection protocols, temporary isolation of infected animals/groups and limiting exposure to insect vectors may help to reduce the scale of outbreaks.
  
 
'''Quarantine''' procedures are in place in many countries when VS is confirmed and these should be adhered to and relevant bodies informed.
 
'''Quarantine''' procedures are in place in many countries when VS is confirmed and these should be adhered to and relevant bodies informed.
 
  
 
{{Learning
 
{{Learning
|Vetstream = [https://www.vetstream.com/canis/search?s=+Vesicular+Stomatitis+Virus Vesicular Stomatitis Virus]
 
 
|flashcards = [[Vesicular Stomatitis Flashcards]]
 
|flashcards = [[Vesicular Stomatitis Flashcards]]
 
}}
 
}}
 
  
 
==References==
 
==References==
 
<references/>
 
<references/>
{{CABI source
+
Animal Health & Production Compendium, '''Vesicular Stomatitis datasheet''', accessed 06/06/2011 @ http://www.cabi.org/ahpc/
|datasheet = [http://www.cabi.org/ahpc/?compid=3&dsid=60393&loadmodule=datasheet&page=2144&site=160 vesicular stomatitis virus] and [http://www.cabi.org/ahpc/?compid=3&dsid=60390&loadmodule=datasheet&page=2144&site=160 vesicular stomatitis]
 
|date = 6 June 2011
 
}}
 
<br><br><br>
 
 
 
 
 
{{review}}
 
 
 
{{OpenPages}}
 
 
 
[[Category:Rhabdoviridae]]
 
[[Category:Zoonoses]]
 
[[Category:Cattle Viruses]]
 
[[Category:Oral Diseases - Cattle]]
 
[[Category:Dermatological Diseases - Cattle]]
 
  
[[Category:Pig Viruses]]
+
Animal Health & Production Compendium, '''Vesicular Stomatitis virus datasheet''', accessed 06/06/2011 @ http://www.cabi.org/ahpc/
[[Category:Oral Diseases - Pig]]
 
[[Category:Dermatological Diseases - Pig]]
 
  
[[Category:Horse Viruses]]
+
[[Category:To Do - CABI review]]
[[Category:Oral Diseases - Horse]]
 
[[Category:Dermatological Diseases - Horse]]
 
[[Category:CABI Expert Review]][[Category:CABI AHPC Pages]]
 
[[Category:Oral Cavity - Vesicular Pathology]]
 

Revision as of 14:10, 25 June 2011

Also Known As – VS

Caused By – Vesicular Stomatitis Virus – VSV – Alagoas Virus – Brazil Virus – Cocal Virus – Piry Virus – Chandipura Virus – Isfahan Virus

Introduction

Vesicular Stomatitis oral lesion in a cow. Copyright CFSPH Iowa State.
Vesicular Stomatitis oral lesion in a horse
Vesicular Stomatitis coronary band lesion

Vesicular Stomatitis is an oral disease of cattle, horses, pigs and people, caused by a rhabdovirus, of which there are two distinct serotypes: VSV-New Jersey (VS-NJ) and VSV-Indiana (VS-IN). Although antibodies have been found in many species of mammal and bird, no clinical signs appear to develop.

The main importance of VS is its identical presentation to Foot and Mouth Disease, in fact they cannot be clinically differentiated.

VS is zoonotic and can cause acute flu-like disease in humans.

This disease is notifiable to the World Organisation for Animal Health (OIE)

Distribution

VS is present exclusively in the Western hemisphere, mainly in the Americas, including parts of the Caribbean and South America.

VS is transmitted by a range of insect vectors including the house fly and Culicoides midge.

The virus can also be transmitted via direct contact with lesions, saliva and fomites.

Signalment

Young animals <1 year old are less likely to exhibit clinical signs although seroconversion occurs.

Disease occurs seasonally in the late Summer and Autumn in endemic countries.

Clinical Signs

VS is characterised by its appearance – beginning as blanched macules and developing into vesicular lesions on the tongue, oral and nasal mucosa, mammary glands, external genitalia and coronary band. When the vesicles rupture after 24-48h, erosions and excoriations remain in the affected mucosa. Hypersalivation often also occurs. Coronary band lesions cause lameness and defective horn growth.

Other clinical manifestations include depression, weight loss, low productivity, agalactia and mastitis. Animals with genital lesions may be reluctant to breed.

Affected animals are often pyrexic, anorexic and dysphagic due to reduced food intake and interference of lesions with prehension/pain when eating.

Shedding ceases 6-7 days post-infection [1] and lesions resolve within 14 days.

Once recovered, animals do not maintain infection or shed the virus.

Deaths from VS are rare and usually due to secondary complications.

Diagnosis

Definitive diagnosis requires laboratory testing. Virus isolation can be attempted from nasal/oral swabs, epithelial tags, skin scrapings or biopsies. Only active lesions will contain infective virus particles. PCR is potentially more sensitive but not widely used.

Serlogical tests are routinely used and will also differentiate serotype. Competitive ELISA (cELISA) is used as a screening test and Serum Neutralisation (SN) and Complement Fixation (CF) are also commonly used to diagnose VS. Tests that detect IgG such as the cELISA and SN may remain positive for up to 3 years after infection.

CF is more indicative of recent infection, especially when rising titres are present.

On histopathology, intercellular oedema is present in the Malphigian cell layer and epithelial cell necrosis is evident. The necrotic cells are strongly eosinophilic and nuclei are pyknotic. Basal cells are separated by vesicular fluid. Other non-specific inflammatory changes are usually also present.

Treatment

Disease is self-limiting and usually requires no treatment. Secondary bacterial infection can delay healing of lesions and usually respond to antibiotics. Symptomatic care may be indicated in severe cases.

Control

Several vaccines are being developed or used experimentally but none are commercially available in the USA.

Appropriate biosecurity, disinfection protocols, temporary isolation of infected animals/groups and limiting exposure to insect vectors may help to reduce the scale of outbreaks.

Quarantine procedures are in place in many countries when VS is confirmed and these should be adhered to and relevant bodies informed.


Vesicular Stomatitis Virus Learning Resources
FlashcardsFlashcards logo.png
Flashcards
Test your knowledge using flashcard type questions
Vesicular Stomatitis Flashcards


References

  1. Katz, J. B., Eernisse, K. A., Landgraf, J. G., Schmitt, B. J. (1997) Comparative performance of four serodiagnostic procedures for detecting bovine and equine vesicular stomatitis virus antibodies. J Vet Diagnostic Investigation, 9(3):329-331; 5

Animal Health & Production Compendium, Vesicular Stomatitis datasheet, accessed 06/06/2011 @ http://www.cabi.org/ahpc/

Animal Health & Production Compendium, Vesicular Stomatitis virus datasheet, accessed 06/06/2011 @ http://www.cabi.org/ahpc/