Difference between revisions of "Feline Medicine Q&A 02"
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| − | '''A 6-year-old neutered male DSH cat presents with crusting lesions around the mouth, ears, ventral abdomen, and nail beds. Histopathology reveals subcorneal pustules with acantholytic keratinocytes.''' | + | '''A 6-year-old neutered male DSH cat presents with crusting lesions around the mouth (184), ears, ventral abdomen, and nail beds. Histopathology reveals subcorneal pustules with acantholytic keratinocytes.''' |
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The clinical signs and histopathology in this cat are typical of pemphigus foliaceous. | The clinical signs and histopathology in this cat are typical of pemphigus foliaceous. | ||
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|q2=What is its cause and how should it be treated? | |q2=What is its cause and how should it be treated? | ||
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However, these are relatively superficial in the epidermis and are very fragile, so are rarely seen. <br><br> | However, these are relatively superficial in the epidermis and are very fragile, so are rarely seen. <br><br> | ||
Erosions and ulcers with crusting and exudation are therefore the common signs. Cytology of exudate may be helpful diagnostically as it may reveal the rounded acantholytic keratinocytes typical of the disease, and immunofluorescence can be used to demonstrate the deposition of antibodies in the lesions. | Erosions and ulcers with crusting and exudation are therefore the common signs. Cytology of exudate may be helpful diagnostically as it may reveal the rounded acantholytic keratinocytes typical of the disease, and immunofluorescence can be used to demonstrate the deposition of antibodies in the lesions. | ||
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|q3=What is the prognosis for the cat? | |q3=What is the prognosis for the cat? | ||
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Glucocorticoids are the treatment of choice (e.g. 2–4 mg/kg/day oral prednisolone, followed by a reducing dose when in remission). <br><br> | Glucocorticoids are the treatment of choice (e.g. 2–4 mg/kg/day oral prednisolone, followed by a reducing dose when in remission). <br><br> | ||
If glucocorticoid-sparing therapy is needed, chlorambucil often produces good results. | If glucocorticoid-sparing therapy is needed, chlorambucil often produces good results. | ||
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</FlashCard> | </FlashCard> | ||
Revision as of 06:36, 9 August 2011
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This question was provided by Manson Publishing as part of the OVAL Project. See more Feline Medicine questions |
[[Image:|centre|500px]]
A 6-year-old neutered male DSH cat presents with crusting lesions around the mouth (184), ears, ventral abdomen, and nail beds. Histopathology reveals subcorneal pustules with acantholytic keratinocytes.
| Question | Answer | Article | |
| What is this disease? | The clinical signs and histopathology in this cat are typical of pemphigus foliaceous. |
[[|Link to Article]] | |
| What is its cause and how should it be treated? | Pemphigus foliaceous is an autoimmune skin disease with deposition of autoantibodies in the epidermis targeted against intercellular adhesion molecules (cadherin desmosomal glycoproteins) causing loss of cellular adhesion.
However, these are relatively superficial in the epidermis and are very fragile, so are rarely seen. |
[[|Link to Article]] | |
| What is the prognosis for the cat? | The prognosis for pemphigus foliaceous is good with most cases responding well to immunosuppressive therapy, although prolonged and sometimes life-long therapy may be required. |
[[|Link to Article]] | |
