Liver Fibrosis

Introduction

Any hepatic injury of a moderate degree or more, is going to cause a degree of fibrosis when the lesion has resolved. Fibrosis occurs due to proliferation of the supportive connective tissue in the liver. Fibrosis isolates the liver cells by effectively changing the sinusoids into capillaries and when a certain amount of fibrosis occurs, it can be self-perpetuating, the end result is a small scarred liver with functional failure.

Patterns of Fibrosis

Centrilobular (periacinar) Fibrosis

This involves fibrosis around the hepatic venule (centrilobular vein). It is associated with chronic toxic injury since hepatocytes in this region are involved in drug metabolism. It is also associated with chronic passive congestion due to long-term right sided congestive heart failure.

Periportal (biliary) Fibrosis

This involves fibrosis that is mostly confined to the portal region, and is associated with chronic inflammatory conditions that lead to inflammation in the portal triads.

Post-Necrotic Scarring

This occurs following massive hepatic necrosis where large areas of parenchyma are lost and replaced by fibrosis.

Bridging (diffuse) Fibrosis

This is the sequel to chronic parenchymal injury, such as prolonged inflammation or numerous episodes of zonal necrosis. Fibrosis occurs throughout lobules and leads to bridging between portal areas, or between portal regions and central veins, causing pseudolobulation.

Although all types of fibrosis can lead to hepatic dysfunction if severe enough, bridging fibrosis is more likely to impair hepatic function than any of the other types.

Hepatic fibrosis is now known to be potentially reversible, provided the source of injury is removed. If the insult persists, however, fibrosis can be self-perpetuating, resulting in a small scarred liver with functional failure.

Also see: Cirrhosis

References

Blood, D.C. and Studdert, V. P. (1999) Saunders Comprehensive Veterinary Dictionary (2nd Edition), Elsevier Science.

Ettinger, S.J. and Feldman, E. C. (2000) Textbook of Veterinary Internal Medicine Diseases of the Dog and Cat Volume 2 (Fifth Edition), W.B. Saunders Company.

Maxie, M.G. (2007) Pathology of Domestic Animals Volume 2 (Fifth Edition), Elsevier Saunders.

McGavin, M.D. and Zachary, J.F. (2007) Pathologic Basis of Veterinary Disease (Fourth Edition), Elsevier Mosby.

Smyth, B (2008) Alimentary System Study Guide, Royal Veterinary College.