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* They are active against gram-negative rods, including enterobacteriaceae.
 
* They are active against gram-negative rods, including enterobacteriaceae.
 
* They are active against the anaerobes, ''Actinomyces'' and ''Fusobacterium'', but inactive against clostridial species and anaerobic cocci.
 
* They are active against the anaerobes, ''Actinomyces'' and ''Fusobacterium'', but inactive against clostridial species and anaerobic cocci.
* Reistance is now widespread.
+
* Resistance is now widespread.
 
* Drugs which contain a PABA nuclear core, such as procaine, antagonise their actions.
 
* Drugs which contain a PABA nuclear core, such as procaine, antagonise their actions.
      
==Pharmacokinetic Considerations==
 
==Pharmacokinetic Considerations==

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