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====Further amplification of inflammation====
====Further amplification of inflammation====
Neutrophils have many mechanisms to increase inflammation. These include [[Cytokines|cytokine]] release and exocytosis of vasoactive peptides as mentioned above. Neutrophil activation in an inflammatory lesion can also result in the release of prostaglandins, through synthesis by cyclo-oxygenase 2, which are responsible for vasoactive changes and for pain (N.B. These are reduced with cyclo-oxygenase (COX) inhibition for example with the NSAID (non-steriodal anti-inflammatory drugs)'s Aspirin and Ibuprofen).
Neutrophils have many mechanisms to increase inflammation. These include [[Cytokines|cytokine]] release and exocytosis of vasoactive peptides as mentioned above. Neutrophil activation in an inflammatory lesion can also result in the release of prostaglandins, through synthesis by cyclo-oxygenase 2, which are responsible for vasoactive changes and for pain (N.B. These are reduced with cyclo-oxygenase (COX) inhibition for example with the NSAID (non-steriodal anti-inflammatory drugs)'s Aspirin and Ibuprofen).
===Interactions===
===Interactions===
<p>Il-6, Il-8 and C5a are all chemoattractants for neutrophils.</p>
<p>Il-6, Il-8 and C5a are all chemoattractants for neutrophils.</p>
===Cell Death===
Neutrophils have a limited life span as they cannot synthesise protein or produce ATP through the electron transfer chain in mitochondria. They hence undergo a process called '''apoptosis''' (otherwise reffered to as ''Programmed Cell Death'' or ''Cell Suicide''). This enables the neutrophils to be cleared by tissue [[Macrophages|macrophages]], and therefore the physiological resolution of inflammation. However, in pathological conditions, where the neutrophils that have undergone apoptosis cannot be cleared as there are too few macrophages, or the pathogen is causing the death of the neutrophils, they undergo a process called '''necrosis'''. This results in the release of all of the intracellular contents, and therefore the amplification of the inflammatory response. It is these neutrophils that have undergone necrosis that forms what is known as '''Pus'''.
===In pathology===
===In pathology===
*Classically a cell involved in [[Acute Inflammation|acute inflammation]]
*Classically a cell involved in [[Acute Inflammation|acute inflammation]]