Changes

An eosinophilic infiltrate may indicate a diet-induced, type 1 hypersensitivity.  However, most dogs do not respond to a purely exclusion diet.  Endoparasitism should also be excluded prior to immunosuppressive therapy for EE.

An eosinophilic infiltrate may indicate a diet-induced, type 1 hypersensitivity.  However, most dogs do not respond to a purely exclusion diet.  Endoparasitism should also be excluded prior to immunosuppressive therapy for EE.

The diffuse form of EE is seen in the dog, cat and horse; it is described as idiopathic but the aetiology has been suggested to be a hypersensitivity reaction. In this form of the condition, recurrent episodes of diarrhoea with tissue and circulatory eosinophilia occurs, with a heavy infiltrate of eosinophils present histologically in all layers of the stomach and intestines.

 

* A disease of young dogs.

** Pin-head sized white nodules can be seen under the serosa in the bowel.

*** Consist of of eosinophils and occasionally macrophages and plasma cells.

*** Can sometimes see [[Toxocara canis|''Toxocara'']] larvae in the nodules.

 

There is a predilection for diffuse EE in:

* Has a predilection for German Shepherd Dogs, but also occcurs in other breeds of dogs and in cats.

Image:Boxer.jpg|'''Boxer'''<p><small>( © Lilly M WikiMedia Commons)</small>

Image:GermanShep.jpg|'''German Shepherd (Alsatian)'''<p><small>( © Ellen Levy Finch WikiMedia Commons)</small>

*** Eosinophils heavily infiltrate all layers of stomach and intestines.

Image:Dobermann.jpg|'''Dobermann'''<p><small>( © John Adams WikiMedia Commons)</small>

**It has been suggested that it is a type of hypersensitivity reaction.

 

Focal EE is a disease of young dogs, which can be associated with [[Toxocara canis|''Toxocara canis'']] infection. Pin-head sized white nodules can be seen under the serosa in the bowel.

*** Consist of of eosinophils and occasionally macrophages and plasma cells.

*** Can sometimes see [[Toxocara canis|''Toxocara'']] larvae in the nodules.

 

==Clinical Signs==

==Clinical Signs==

==Treatment==

==Treatment==

Anti-parasiticide (Fenbendazole) treatment may be given due to the possible endoparasitism or dietary sensitivity. Dietary modification is required with a chamge to a hypoallergenic diet.

Anti-parasiticide (Fenbendazole) treatment may be given due to the possible endoparasitism or dietary sensitivity. Dietary modification is required with a change to a hypoallergenic diet.

Immunosuppressive therapy may also be required.

Immunosuppressive therapy may also be required.

*Hall, E.J, Simpson, J.W. and Williams, D.A. (2005) '''BSAVA Manual of Canine and Feline Gastroenterology (2nd Edition)''' ''BSAVA''

*Hall, E.J, Simpson, J.W. and Williams, D.A. (2005) '''BSAVA Manual of Canine and Feline Gastroenterology (2nd Edition)''' ''BSAVA''

*Nelson, R.W. and Couto, C.G. (2009) '''Small Animal Internal Medicine (Fourth Edition)''' ''Mosby Elsevier''.

*Nelson, R.W. and Couto, C.G. (2009) '''Small Animal Internal Medicine (Fourth Edition)''' ''Mosby Elsevier''.

[[Category:Dog]][[Category:Intestine_-_Inflammatory_Pathology_by_Type]]

[[Category:Intestinal Diseases - Dog]][[Category:Intestine_-_Inflammatory_Pathology_by_Type]]

[[Category:To Do - Clinical]]