Difference between revisions of "Category:Paramyxoviridae"

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==Morphology==
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<categorytree mode=pages>Paramyxoviridae</categorytree>
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*Single-stranded negative-sense unsegmented RNA virus
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*Reassortment and antigenic shift cannot occur
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*Spike proteins include
 
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**'''HN''' (Haemagglutinin and Neuraminidase)
 
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**'''F''' (Fusion glycoprotein), which allows the virus to fuse directly to the plasma membrane and release its RNA
 
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***F also causes syncitium to form, which aids diagnosis
 
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***Host antibody response to the F protein is the basis for vaccination
 
  
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==Virulence==
 
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*Paramyxoviruses replicate in the epithelium of the upper respiratory tract as well as occasionally in the gut
 
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**Sites of spike protein cleavage
 
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*Virulence varies by virus, see below
 
  
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==Types and Subtypes==
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{{Learning |Vetstream = <p>[https://www.vetstream.com/canis/Content/Bug/bug00215.asp Canine Distemper]</p><p>[https://www.vetstream.com/canis/Content/Bug/bug00210.asp Canine Parainfluenza Virus 2]</p>}}
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Paramoyxoviridae was reclassified in 2000 to include 2 subfamilies and 5 genera, of interest including:
 
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*Subfamily: ''[[Paramyxovirinae]]'':
 
  
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*Subfamily: ''[[Pneumovirinae]]''
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[[Category:Viral Organisms]]
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==Antigenic Variation==
 
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*Antigenic conservation allows some cross protection by vaccination:
 
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**Conservation of major virus-specific F/HN antigens means vaccines protect against '''all isolates''' of the same virus
 
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**Minor morbillivirus-specific epitopes on F allows some cross protection between '''canine distemper, measles, and rinderpest'''
 
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*Antigenic "fingerprinting" is possible for some viruses based on minor variable epitopes of HN, F and NP on specific isolates as detected by monoclonal antibodies
 
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**These are detected by immunostaining infected cells
 
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=Other resources=
 
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*[http://www.pitt.edu/~super1/lecture/lec3401/index.htm On line Paramyxoviridae lecture by P. Russell]
 
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[[Category:Viruses]]
 

Latest revision as of 00:00, 16 June 2016

Paramyxoviridae

Content

▼ Paramyxoviridae
► Paramyxovirinae
► Pneumovirinae
  Paramyxoviridae - Overview
  Avian Pneumovirus
  Blue Eye Disease




Paramyxoviridae Learning Resources
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Subcategories

This category has the following 2 subcategories, out of 2 total.

P

Pages in category "Paramyxoviridae"

The following 3 pages are in this category, out of 3 total.

A

B

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