Difference between revisions of "Liver Fibrosis"

Latest revision as of 19:28, 25 June 2016

Introduction

Fibrosis is one way in which the liver responds to injury. It commonly occurs in association with chronic hepatic injury, and represents a repair stage in response to diseases that lead to necrosis and inflammation. The process is complex and involves increased deposition of extracellular matrix in the liver, following injury-induced activation of stellate cells.

The distribution pattern of fibrosis is a reflection of the pathogenesis of the condition, and can indicate the type of underlying pathology.

Patterns of Fibrosis

Centrilobular (periacinar) Fibrosis

This involves fibrosis around the hepatic venule (centrilobular vein). It is associated with chronic toxic injury since hepatocytes in this region are involved in drug metabolism. It is also associated with chronic passive congestion due to long-term right sided congestive heart failure.

Periportal (biliary) Fibrosis

This involves fibrosis that is mostly confined to the portal region, and is associated with chronic inflammatory conditions that lead to inflammation in the portal triads.

Post-Necrotic Scarring

This occurs following massive hepatic necrosis where large areas of parenchyma are lost and replaced by fibrosis.

Bridging (diffuse) Fibrosis

This is the sequel to chronic parenchymal injury, such as prolonged inflammation or numerous episodes of zonal necrosis. Fibrosis occurs throughout lobules and leads to bridging between portal areas, or between portal regions and central veins, causing pseudolobulation.

Although all types of fibrosis can lead to hepatic dysfunction if severe enough, bridging fibrosis is more likely to impair hepatic function than any of the other types.

Hepatic fibrosis is now known to be potentially reversible, provided the source of injury is removed. If the insult persists, however, fibrosis can be self-perpetuating, resulting in a small scarred liver with functional failure.

Also see: Cirrhosis

Liver Fibrosis Learning Resources
Vetstream To reach the Vetstream content, please select	Canis, Felis, Lapis or Equis

References

Blood, D.C. and Studdert, V. P. (1999) Saunders Comprehensive Veterinary Dictionary (2nd Edition), Elsevier Science.

Ettinger, S.J. and Feldman, E. C. (2000) Textbook of Veterinary Internal Medicine Diseases of the Dog and Cat Volume 2 (Fifth Edition), W.B. Saunders Company.

Maxie, M.G. (2007) Pathology of Domestic Animals Volume 2 (Fifth Edition), Elsevier Saunders.

McGavin, M.D. and Zachary, J.F. (2007) Pathologic Basis of Veterinary Disease (Fourth Edition), Elsevier Mosby.

Smyth, B (2008) Alimentary System Study Guide, Royal Veterinary College.

@@ Line 1: / Line 1: @@
 == Introduction ==
-Any hepatic injury of a moderate degree or more, is going to cause a degree of fibrosis when the lesion has resolved. Fibrosis occurs due to proliferation of the supportive connective tissue in the liver. Fibrosis isolates the [[Liver - Anatomy & Physiology|liver]] cells by effectively changing the sinusoids into capillaries and when a certain amount of fibrosis occurs, it can be self-perpetuating, the end result is a small scarred liver with functional failure.
+Fibrosis is one way in which the liver responds to injury. It commonly occurs in association with chronic hepatic injury, and represents a repair stage in response to diseases that lead to [[Liver Necrosis|necrosis]] and inflammation. The process is complex and involves increased deposition of extracellular matrix in the liver, following injury-induced activation of [[Hepatic Stellate Cells|stellate cells]].
+The distribution pattern of fibrosis is a reflection of the pathogenesis of the condition, and can indicate the type of underlying pathology.
-== Types of Fibrosis ==
+==Patterns of Fibrosis ==
-=====Periacinar Fibrosis=====
+===Centrilobular (periacinar) Fibrosis===
-In this type of fibrosis, the fibrous area surrounds the hepatic venule (centrilobular vein). This can be seen when there is chronic passive congestion with atrophy of the surrounding periacinar hepatocytes and condensation of the remaining connective tissue.
+This involves fibrosis around  the hepatic venule (centrilobular vein). It is associated with chronic toxic injury since hepatocytes in this region are involved in drug metabolism. It is also associated with chronic passive congestion due to long-term [[Heart Failure, Right-Sided|right sided congestive heart failure]].
+===Periportal (biliary) Fibrosis===
+This involves fibrosis that is mostly confined to the portal region, and is associated with chronic inflammatory conditions that lead to inflammation in the portal triads.
-=====Biliary Fibrosis=====
+===Post-Necrotic Scarring===
-This usually occurs along with another type of fibrosis and will accompany inflammation centered on the portal triads.
+This occurs following massive hepatic necrosis where  large areas of parenchyma are lost and replaced by fibrosis.
-=====Post-Necrotic Scarring=====
+===Bridging (diffuse) Fibrosis===
-This type of fibrosis occurs following massive necrosis where the necrotic cells are removed and the defect is repaired by fibrosis. It is seen histopathologically as bands of fibrous tissue.
+This is the sequel to chronic parenchymal injury, such as prolonged inflammation or numerous episodes of zonal necrosis. Fibrosis occurs throughout lobules and leads to bridging between portal areas, or between portal regions and central veins, causing pseudolobulation.
-=====Diffuse Fibrosis=====
+Although all types of fibrosis can lead to hepatic dysfunction if severe enough, bridging fibrosis is more likely to impair hepatic function than any of the other types.
-This occurs after repeated damage to one or more zones. The fibrosis generated proliferates throughout to involve all the tissue.
+Hepatic fibrosis is now known to be potentially reversible, provided the source of injury is removed. If the insult persists, however, fibrosis can be self-perpetuating, resulting in a small scarred liver with functional failure.
+<big><b>Also see: [[Cirrhosis]]</b></big>
+{{Learning
+|Vetstream = [https://www.vetstream.com/canis/search?s=cirrhosis Cirrhosis]<br>[https://www.vetstream.com/canis/Content/Disease/dis01098.asp Idiopathic fibrosis in dogs]
+}}
 == References ==
 Blood, D.C. and Studdert, V. P. (1999) '''Saunders Comprehensive Veterinary Dictionary''' (2nd Edition), ''Elsevier Science''.
-<br>
 Ettinger, S.J. and Feldman, E. C. (2000) '''Textbook of Veterinary Internal Medicine Diseases of the Dog and Cat''' Volume 2 (Fifth Edition),'' W.B. Saunders Company.''
-<br>
+Maxie, M.G. (2007) '''Pathology of Domestic Animals Volume''' 2 (Fifth Edition), ''Elsevier Saunders''.
+McGavin, M.D. and Zachary, J.F. (2007) '''Pathologic Basis of Veterinary Disease''' (Fourth Edition), ''Elsevier Mosby''.
 Smyth, B (2008) ''' Alimentary System Study Guide, ''''' Royal Veterinary College.''
+{{Nicky Parry
+|date = 22 August 2011
+}}
 [[Category:Liver_-_General_Pathology]]
-[[Category:Nicola Parry reviewing]]
+[[Category:Nicola Parry reviewed]]