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IGF-1 - Anatomy & Physiology (view source)
Revision as of 17:08, 8 December 2016
, 17:08, 8 December 2016→Overview
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==Overview==
[[Image:IGF1.png|250px|thumb|right|Danielle Keller
2007 '''Schematic structure of Insulin-like growth factor-1.''']]
The Liver is the main source of IGF-1.
IGF-1 is one of a number of insulin-like growth factors. Insulin-like growth factors are produced by many different tissues and have local paracrine and autocrine effects. (see [[Hormones - Anatomy & Physiology|hormones]] for further details). They bind to carrier proteins to extend their half life in the blood. The [[Liver - Anatomy & Physiology|'''liver''']] is the main source of IGF-1. Hormones that directly stimulate Insulin-like growth factor-I (IGF-I) include growth hormone, insulin and oestradiol.Growth hormone is the main regulator of IGF-I production in the liver and insulin and oestradiol are stimulatory in other tissues.
==Actions of IGF-1==
==Actions of IGF-1==
Increased '''protein synthesis''' and increased '''chondrogenesis''', both promoting growth.
[[Category:Endocrine System]]
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[[Category:Endocrine System - Anatomy & Physiology]]
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