IGF-1 - Anatomy & Physiology

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Danielle Keller 2007 Schematic structure of Insulin-like growth factor-1.

IGF-1 is one of a number of insulin-like growth factors. Insulin-like growth factors are produced by many different tissues and have local paracrine and autocrine effects. (see hormones for further details). They bind to carrier proteins to extend their half life in the blood. The liver is the main source of IGF-1. Hormones that directly stimulate Insulin-like growth factor-I (IGF-I) include growth hormone, insulin and oestradiol.Growth hormone is the main regulator of IGF-I production in the liver and insulin and oestradiol are stimulatory in other tissues.

Actions of IGF-1

Increased protein synthesis and increased chondrogenesis, both promoting growth.

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