Difference between revisions of "Testicular Feminisation"

Revision as of 11:16, 15 July 2008

Genotype XY as should be in the male.
Testes develop normally and secrete Androgens and MIH
Foetal genetalia are genetically insensitive to the actions of Androgens due to a point mutation in the Androgen receptor.

Wolffian Ducts regress, allowing formation of female external genetalia:
- Labia
- Clitoris
- Vagina
Sertoli cells are present and continue to secrete MIH, causing Mullarian Duct regression.
Since both Wolffian AND Mullarian Ducts regress, there is no internal genetalia.

@@ Line 1: / Line 1: @@
-#redirect[[Intersex#Testicular feminisation]]
+<big><center>[[Reproductive System|'''BACK TO REPRODUCTIVE SYSTEM''']]</center></big>
+<big><center>[[Reproductive_System#Fertilisation.2C_Implantation_and_Early_Embryonic_Development|'''BACK TO FERTILISATION , IMPLANTATION and EARLY EMBRYONIC DEVELOPMENT''']]</center></big>
+<big><center>[[Fertilisation%2C_Implantation_and_Early_Embryonic_Development_-Sexual_Differentiation-_Anatomy_%26_Physiology#Associated_Disorders|'''BACK TO SEXUAL DIFFERENTIATION''']]</center></big>
+== Aetiology ==
+* Genotype XY as should be in the male.
+* Testes develop normally and secrete Androgens and MIH
+* Foetal genetalia are genetically insensitive to the actions of Androgens due to a point mutation in the Androgen receptor.
+== Consequence ==
+* Wolffian Ducts regress, allowing formation of '''female external genetalia''':
+** Labia
+** Clitoris
+** Vagina
+* Sertoli cells are present and continue to secrete MIH, causing Mullarian Duct regression.
+* Since both Wolffian AND Mullarian Ducts regress, there is '''no internal genetalia'''.