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→Pathology
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Also known as: '''''CAV-1 — Infectious Canine Hepatitis Virus — ICH virus'''''
Also known as: '''''CAV-1 - Infectious Canine Hepatitis Virus - ICH virus'''''
==Introduction==
==Introduction==
==Pathology==
==Pathology==
Subclinical infection with canine adenovirus 1 most typically causes a mild bronchointerstitial pneumonia, although a necrotising bronchiolitis may occur in immunocompromised dogs. Bronchointerstitial pneumonia is seen histologcally as necrosis of the bronchiolar and alveolar epithelium, pulmonary oedema and hyperplasia of type II pneumocytes.
Subclinical infection with canine adenovirus 1 most typically causes a mild bronchointerstitial pneumonia, although a necrotising bronchiolitis may occur in immunocompromised dogs. Bronchointerstitial pneumonia is seen histologically as necrosis of the bronchiolar and alveolar epithelium, pulmonary oedema and hyperplasia of type II pneumocytes.
In [[Infectious Canine Hepatitis]], canine adenovirus 1 principally causes damage to the endothelium and to hepatic cells. Endothelial damage results in widespread petechial haemorrhages, and hepatic damage may be visualised as an enlarged liver, mottled with areas of necrosis. Microscopically, centrolobular necrosis is seen in the liver, and adenoviral nuclear inclusion bodies may be observed in Kupffer and parenchymal cells. Glomerulonephritis and occular pathology are not uncommon findings.
In [[Infectious Canine Hepatitis]], canine adenovirus 1 principally causes damage to the endothelium and to hepatic cells. Endothelial damage results in widespread petechial haemorrhages, and hepatic damage may be visualised as an enlarged liver, mottled with areas of necrosis. Microscopically, centrolobular necrosis is seen in the liver, and adenoviral nuclear inclusion bodies may be observed in Kupffer and parenchymal cells. Glomerulonephritis and occular pathology are not uncommon findings.
The pathology exhibited in [[Infectious Canine Tracheobronchitis]] varies with the other contributing organisms and the severity of disease.
The pathology exhibited in [[Infectious Canine Tracheobronchitis]] varies with the other contributing organisms and the severity of disease.
==Literature Search==
{{Learning
|literature search = [http://www.cabdirect.org/search.html?rowId=1&options1=AND&q1=%22canine+adenovirus%22&occuring1=title&rowId=2&options2=AND&q2=&occuring2=title&rowId=3&options3=AND&q3=&occuring3=freetext&x=44&y=11&publishedstart=2000&publishedend=yyyy&calendarInput=yyyy-mm-dd&la=any&it=any&show=all Canine adenovirus recent literature]
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[http://www.cabdirect.org/search.html?rowId=1&options1=AND&q1=%22canine+adenovirus+1%22&occuring1=freetext&rowId=2&options2=AND&q2=&occuring2=freetext&rowId=3&options3=AND&q3=&occuring3=freetext&publishedstart=2000&publishedend=2010&calendarInput=yyyy-mm-dd&la=any&it=any&show=all&x=37&y=11 Canine adenovirus - 1 recent literature]
==References==
==References==
#Merck & Co (2008) '''The Merck Veterinary Manual (Eighth Edition)''' ''Merial''
#Merck & Co (2008) '''The Merck Veterinary Manual (Eighth Edition)''' ''Merial''
[[Category:Adenoviridae]][[Category:Dog]]
[[Category:To_Do_-_Lizzie]]
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[[Category:Adenoviridae]][[Category:Dog Viruses]][[Category:Respiratory Diseases - Dog]]
[[Category:Expert_Review]]
[[Category:Expert_Review]]
[[Category:Respiratory_Viral_Infections]]
[[Category:Respiratory_Viral_Infections]]