Changes

Increased blood urea nitrogen with normal serum creatinine can be seen with gastrointestinal haemorrhage.

Increased blood urea nitrogen with normal serum creatinine can be seen with gastrointestinal haemorrhage.

References: [[/en.wikivet.net/NationWide Laboratories|NationWide Laboratories]]  

References: [[NationWide Laboratories]]  

Any form of spontaneous haemorrhage with no apparent cause may suggest the presence of an underlying coagulopathy.  The most common haemorrhagic presentations are:

Any form of spontaneous haemorrhage with no apparent cause may suggest the presence of an underlying coagulopathy.  The most common haemorrhagic presentations are:

* Haemolytic anaemias often result in a degree of hyperbilirubinaemia which, if sufficiently severe, will be evident as icterus. RBC destruction leads to an increased level of unconjugated bilirubin which exceeds the rate of hepatic excretion. Acute severe anaemia may also cause hypoxic or toxic hepatic injury, resulting in decreased bilirubin metabolism and cholestasis. Although hyperbilirubinaemia results primarily from increased unconjugated bilirubin, conjugated bilirubin also increases and leads to bilirubinuria. Evaluation of unconjugated versus conjugated bilirubin is often not helpful when trying to differentiate between pre-hepatic and hepatic jaundice.

* Haemolytic anaemias often result in a degree of hyperbilirubinaemia which, if sufficiently severe, will be evident as icterus. RBC destruction leads to an increased level of unconjugated bilirubin which exceeds the rate of hepatic excretion. Acute severe anaemia may also cause hypoxic or toxic hepatic injury, resulting in decreased bilirubin metabolism and cholestasis. Although hyperbilirubinaemia results primarily from increased unconjugated bilirubin, conjugated bilirubin also increases and leads to bilirubinuria. Evaluation of unconjugated versus conjugated bilirubin is often not helpful when trying to differentiate between pre-hepatic and hepatic jaundice.

References: [[/en.wikivet.net/NationWide Laboratories|NationWide Laboratories]]  

References: [[NationWide Laboratories]]  

 

 

Haemolysis may occur in the following processes:

Haemolysis may occur in the following processes:

*'''Immune-mediated disease''' including [[Immune Mediated Haemolytic Anaemia]] and [[Neonatal Isoerythrolysis]].

*'''Immune-mediated disease''' including [[Immune Mediated Haemolytic Anaemia]] and [[Neonatal Isoerythrolysis]].