Difference between revisions of "Glutamate dehydrogenase"
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== GLDH Introduction == | == GLDH Introduction == | ||
''Virtually liver specific, this enzyme is localised almost exclusively in the mitochondria of hepatocytes. It is generally considered that a severe insult is required to bring about its release and it is therefore not a sensitive general marker for hepatic disease. However, GLDH has been demonstrated to be a sensitive marker of hepatocellular necrosis in the dog irrespective of its severity.'' | ''Virtually liver specific, this enzyme is localised almost exclusively in the mitochondria of hepatocytes. It is generally considered that a severe insult is required to bring about its release and it is therefore not a sensitive general marker for hepatic disease. However, GLDH has been demonstrated to be a sensitive marker of hepatocellular necrosis in the dog irrespective of its severity.'' | ||
Revision as of 10:56, 25 March 2022
GLDH Introduction
Virtually liver specific, this enzyme is localised almost exclusively in the mitochondria of hepatocytes. It is generally considered that a severe insult is required to bring about its release and it is therefore not a sensitive general marker for hepatic disease. However, GLDH has been demonstrated to be a sensitive marker of hepatocellular necrosis in the dog irrespective of its severity.
Small Animals
Causes of increased GLDH activity
- Hepatocellular necrosis
- Secondary hepatopathies (for example, congestive heart failure and small intestinal pathology)
Complementary tests
ALT, albumin, bilirubin and bile acids.
Equine
GLDH has a relatively short half life in the horse (12-14 hours) compared to LDH, AST and GGT. Elevated levels therefore indicate active hepatocellular damage.
Causes of increased GLDH activity
- Hepatocellular necrosis
- Enteropathy – common and levels can be quite high
Complementary tests
AST, GGT (hepatocellular damage) and bile acids (hepatic function).