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<div style="text-align: center;">
</div>
==Granulopoiesis==
==Granulopoiesis==
All granulocytes develop from the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]] cells.
All granulocytes develop from the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]] cells.
+
===Summary of pathways===
===Summary of pathways===
−{| cellpadding="10" cellspacing="0" border="1" align="left"
{| cellpadding="10" cellspacing="0" border="1" align="left"
|
|
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!Basophil
!Basophil
!Eosinophil
!Eosinophil
−|rowspan="10"|<p>[[Image:LH_Developing_granulocytes_Histology.jpg|200px|Developing granulocytes]]</p><sup>©RVC 2008</sup>
+| rowspan="10" |<p>[[Image:LH_Developing_granulocytes_Histology.jpg|200px|Developing granulocytes]]</p><sup>©RVC 2008</sup>
|-
|-
!Stem cell
!Stem cell
−|colspan="4"|CFU-GEMM
+| colspan="4" |CFU-GEMM
|-
|-
!CFU
!CFU
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|<p>GM-CSF</p><p>IL-3</p><p>M-CSF</p>
|<p>GM-CSF</p><p>IL-3</p><p>M-CSF</p>
|<p>GM-CSF</p><p>IL-3</p><p>G-CSF</p>
|<p>GM-CSF</p><p>IL-3</p><p>G-CSF</p>
−|valign="top"|<p>GM-CSF</p><p>IL-3</p>
+| valign="top" |<p>GM-CSF</p><p>IL-3</p>
|<p>GM-CSF</p><p>IL-3</p><p>IL-5</p>
|<p>GM-CSF</p><p>IL-3</p><p>IL-5</p>
|-
|-
−!Rowspan="6"|Stages
+! rowspan="6" |Stages
|Monoblast
|Monoblast
−|colspan="3"|Myelocyte
+| colspan="3" |Myelocyte
|-
|-
|Promonocyte
|Promonocyte
−|colspan="3"|Promyelocyte
+| colspan="3" |Promyelocyte
|-
|-
−|rowspan="4"|Monocyte
+| rowspan="4" |Monocyte
|Neutrophilic Myelocyte
|Neutrophilic Myelocyte
|Basophilic Myelocyte
|Basophilic Myelocyte
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|-
|-
|Neutrophilic Metamyelocyte
|Neutrophilic Metamyelocyte
−|rowspan="2"|Basophilic Metamyelocyte
+| rowspan="2" |Basophilic Metamyelocyte
−|rowspan="2"|Eosinophilic Metamyelocyte
+| rowspan="2" |Eosinophilic Metamyelocyte
|-
|-
|Band Cell
|Band Cell
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|Eosinophil
|Eosinophil
|}
|}
−<Br clear="left">
<Br clear="left">
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==Basophils==
==Basophils==
−Under the stimulation of GM-CSF and Il-3, the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]] differentiates into [[Haematopoiesis - Overview#Colony Forming Units|CFU-Ba]].
+Under the stimulation of GM-CSF and IL-3, the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]] differentiates into [[Haematopoiesis - Overview#Colony Forming Units|CFU-Ba]].
===Stages:===
===Stages:===
====Myeloblast & Promyelocyte====
====Myeloblast & Promyelocyte====
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==Eosinophils==
==Eosinophils==
−Under the stimulation of GM-CSF, Il-3 and Il-5 the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]] differentiates into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-Eo]].
+Under the stimulation of GM-CSF, IL-3 and IL-5 the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]] differentiates into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-Eo]].
===Stages:===
===Stages:===
====Myeloblast & Promyelocyte====
====Myeloblast & Promyelocyte====
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|colspan="4"|CFU-L
|colspan="4"|CFU-L
|-align="center"
|-align="center"
−|style="background-color:#ffffcc"|<sup>▼Il-7 & Il-11</sup>
+|style="background-color:#ffffcc"|<sup>▼IL-7 & IL-11</sup>
−|colspan="3" style="background-color:#e6e6fa"|<sup>▼Il-7 & SCF</sup>
+|colspan="3" style="background-color:#e6e6fa"|<sup>▼IL-7 & SCF</sup>
|-align="center"
|-align="center"
|style="background-color:#ffffcc"|B lymphoid cell progenitor
|style="background-color:#ffffcc"|B lymphoid cell progenitor
|colspan="3" style="background-color:#e6e6fa"|T lymphoid cell progenitor
|colspan="3" style="background-color:#e6e6fa"|T lymphoid cell progenitor
|-align="center"
|-align="center"
−|style="background-color:#ffffcc"|<sup>▼Il-3 & Il-7</sup>
+|style="background-color:#ffffcc"|<sup>▼IL-3 & IL-7</sup>
−|style="background-color:#e6e6fa"|<sup>▼Il-7</sup>
+|style="background-color:#e6e6fa"|<sup>▼IL-7</sup>
−|style="background-color:#e6e6fa"|<sup>▼Il-2, IL-12 & Il-18</sup>
+|style="background-color:#e6e6fa"|<sup>▼IL-2, IL-12 & IL-18</sup>
−|style="background-color:#e6e6fa"|<sup>▼Il-3, Il-6, GM-CSF & SCF</sup>
+|style="background-color:#e6e6fa"|<sup>▼IL-3, IL-6, GM-CSF & SCF</sup>
|-align="center"
|-align="center"
|style="background-color:#ffffcc"|Pre-B cell
|style="background-color:#ffffcc"|Pre-B cell
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<p>'''Note:'''
<p>'''Note:'''
*Between the 'pre-[type] cell' stage and the final mature all the lymphocytes are referred to as 'immature [type] cells'.
*Between the 'pre-[type] cell' stage and the final mature all the lymphocytes are referred to as 'immature [type] cells'.
−* T cell differentiation into helper, cytotoxic and T cells with regulator functions is induced by Il-10 & TNF-γ</p>
+* T cell differentiation into helper, cytotoxic and T cells with regulator functions is induced by IL-10 & TNF-γ
[[Category:Haematopoiesis]]
[[Category:Haematopoiesis]]