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Leukopoiesis (view source)

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All granulocytes develop from the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]] cells.
 
All granulocytes develop from the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]] cells.
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A left shift is seen when immature granulocytes are released due to increased tissue demands. These immature cells are predominantly band neutrophils although metamyelocytes and occasionally myelocytes may be seen. Reference: [[NationWide Laboratories]]
   
===Summary of pathways===
 
===Summary of pathways===
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<div style="text-align: center;">
   
{| cellpadding="10" cellspacing="0" border="1" align="left"
 
{| cellpadding="10" cellspacing="0" border="1" align="left"
 
|
 
|
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!Basophil
 
!Basophil
 
!Eosinophil
 
!Eosinophil
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|rowspan="10"|<p>[[Image:LH_Developing_granulocytes_Histology.jpg|200px|Developing granulocytes]]</p><sup>©RVC 2008</sup>
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| rowspan="10" |<p>[[Image:LH_Developing_granulocytes_Histology.jpg|200px|Developing granulocytes]]</p><sup>©RVC 2008</sup>
 
|-
 
|-
 
!Stem cell
 
!Stem cell
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|colspan="4"|CFU-GEMM
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| colspan="4" |CFU-GEMM
 
|-
 
|-
 
!CFU
 
!CFU
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|<p>GM-CSF</p><p>IL-3</p><p>M-CSF</p>
 
|<p>GM-CSF</p><p>IL-3</p><p>M-CSF</p>
 
|<p>GM-CSF</p><p>IL-3</p><p>G-CSF</p>
 
|<p>GM-CSF</p><p>IL-3</p><p>G-CSF</p>
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|valign="top"|<p>GM-CSF</p><p>IL-3</p>
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| valign="top" |<p>GM-CSF</p><p>IL-3</p>
 
|<p>GM-CSF</p><p>IL-3</p><p>IL-5</p>
 
|<p>GM-CSF</p><p>IL-3</p><p>IL-5</p>
 
|-
 
|-
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!Rowspan="6"|Stages
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! rowspan="6" |Stages
 
|Monoblast
 
|Monoblast
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|colspan="3"|Myelocyte
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| colspan="3" |Myelocyte
 
|-
 
|-
 
|Promonocyte
 
|Promonocyte
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|colspan="3"|Promyelocyte
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| colspan="3" |Promyelocyte
 
|-
 
|-
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|rowspan="4"|Monocyte
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| rowspan="4" |Monocyte
 
|Neutrophilic Myelocyte
 
|Neutrophilic Myelocyte
 
|Basophilic Myelocyte
 
|Basophilic Myelocyte
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|-
 
|-
 
|Neutrophilic Metamyelocyte
 
|Neutrophilic Metamyelocyte
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|rowspan="2"|Basophilic Metamyelocyte
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| rowspan="2" |Basophilic Metamyelocyte
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|rowspan="2"|Eosinophilic Metamyelocyte
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| rowspan="2" |Eosinophilic Metamyelocyte
 
|-
 
|-
 
|Band Cell
 
|Band Cell
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|Eosinophil
 
|Eosinophil
 
|}
 
|}
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</div>
   
<Br clear="left">
 
<Br clear="left">
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<p>'''Note:'''
 
<p>'''Note:'''
 
*Between the 'pre-[type] cell' stage and the final mature all the lymphocytes are referred to as 'immature [type] cells'.  
 
*Between the 'pre-[type] cell' stage and the final mature all the lymphocytes are referred to as 'immature [type] cells'.  
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* T cell differentiation into helper, cytotoxic and T cells with regulator functions is induced by IL-10 & TNF-γ</p>
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* T cell differentiation into helper, cytotoxic and T cells with regulator functions is induced by IL-10 & TNF-γ
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[[File:NationWide Logo.jpeg|right|link=https://www.nwlabs.co.uk/|alt=NationWide Logo|240x240px|In Partnership with NationWide Laboratories|frameless|thumb|]]
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== References ==
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Text referenced 'Nationwide Laboratories': [[NationWide Laboratories]]
   
[[Category:Haematopoiesis]]
 
[[Category:Haematopoiesis]]
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