Changes

==Granulopoiesis==

==Granulopoiesis==

All granulocytes develop from the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]] cells.

All granulocytes develop from the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]] cells.

===Summary of pathways===

===Summary of pathways===

{| cellpadding="10" cellspacing="0" border="1" align="left"

{| cellpadding="10" cellspacing="0" border="1" align="left"

|

|

!Basophil

!Basophil

!Eosinophil

!Eosinophil

|rowspan="10"|<p>[[Image:LH_Developing_granulocytes_Histology.jpg|200px|Developing granulocytes]]</p>^{©RVC 2008}

| rowspan="10" |<p>[[Image:LH_Developing_granulocytes_Histology.jpg|200px|Developing granulocytes]]</p>^{©RVC 2008}

|-

|-

!Stem cell

!Stem cell

|colspan="4"|CFU-GEMM

| colspan="4" |CFU-GEMM

|-

|-

!CFU

!CFU

|CFU-Eo

|CFU-Eo

|-

|-

!Factors

!Cytokines

|<p>GM-CSF</p><p>Il-3</p><p>M-CSF</p>

|<p>GM-CSF</p><p>IL-3</p><p>M-CSF</p>

|<p>GM-CSF</p><p>Il-3</p><p>G-CSF</p>

|<p>GM-CSF</p><p>IL-3</p><p>G-CSF</p>

|valign="top"|<p>GM-CSF</p><p>Il-3</p>

| valign="top" |<p>GM-CSF</p><p>IL-3</p>

|<p>GM-CSF</p><p>Il-3</p><p>Il-5</p>

|<p>GM-CSF</p><p>IL-3</p><p>IL-5</p>

|-

|-

!Rowspan="6"|Stages

! rowspan="6" |Stages

|Monoblast

|Monoblast

|colspan="3"|Myelocyte

| colspan="3" |Myelocyte

|-

|-

|Promonocyte

|Promonocyte

|colspan="3"|Promyelocyte

| colspan="3" |Promyelocyte

|-

|-

|rowspan="4"|Monocyte

| rowspan="4" |Monocyte

|Neutrophilic Myelocyte

|Neutrophilic Myelocyte

|Basophilic Myelocyte

|Basophilic Myelocyte

|-

|-

|Neutrophilic Metamyelocyte

|Neutrophilic Metamyelocyte

|rowspan="2"|Basophilic Metamyelocyte

| rowspan="2" |Basophilic Metamyelocyte

|rowspan="2"|Eosinophilic Metamyelocyte

| rowspan="2" |Eosinophilic Metamyelocyte

|-

|-

|Band Cell

|Band Cell

|Eosinophil

|Eosinophil

|}

|}

<Br clear="left">

<Br clear="left">

==Neutrophils==

==Neutrophils==

Under the stimulation of GM-CSF, G-CSF and Il-3 the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]] differentiates into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GM]], the common precursor for both neutrophils and monocytes. This then further differentiates into [[Haematopoiesis - Overview#Colony Forming Units|CFU-G]].

Under the stimulation of [[Cytokines|cytokines]] GM-CSF, G-CSF and IL-3 the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]] differentiates into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GM]], the common precursor for both neutrophils and monocytes. This then further differentiates into [[Haematopoiesis - Overview#Colony Forming Units|CFU-G]].

===Stages:===

===Stages:===

====Myeloblast====

====Myeloblast====

==Basophils==

==Basophils==

Under the stimulation of GM-CSF and Il-3, the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]] differentiates into [[Haematopoiesis - Overview#Colony Forming Units|CFU-Ba]].

Under the stimulation of GM-CSF and IL-3, the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]] differentiates into [[Haematopoiesis - Overview#Colony Forming Units|CFU-Ba]].

===Stages:===

===Stages:===

====Myeloblast & Promyelocyte====

====Myeloblast & Promyelocyte====

==Eosinophils==

==Eosinophils==

Under the stimulation of GM-CSF, Il-3 and Il-5 the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]] differentiates into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-Eo]].

Under the stimulation of GM-CSF, IL-3 and IL-5 the [[Haematopoiesis - Overview#Colony Forming Units|CFU-GEMM]] differentiates into the [[Haematopoiesis - Overview#Colony Forming Units|CFU-Eo]].

===Stages:===

===Stages:===

====Myeloblast & Promyelocyte====

====Myeloblast & Promyelocyte====

==Lymphopoiesis==

==Lymphopoiesis==

[[Lymphocytes - Introduction|Lymphocytes]] develop from the [[Haematopoiesis - Overview#Colony Forming Units|CFU-L]]'s. Those destined to become [[T cells]] leave the [[Bone Marrow - Anatomy & Physiology|bone marrow]] and migrate to the [[Thymus - Anatomy & Physiology|thymus]], and those destined to be [[B cells]] migrate to the [[Spleen - Anatomy & Physiology|spleen]] and gut-associated lymphoid tissue (GALT) or proliferate directly from the bone marrow]].

[[Lymphocytes - Introduction|Lymphocytes]] develop from the [[Haematopoiesis - Overview#Colony Forming Units|CFU-L]]'s. Those destined to become [[T cells]] leave the [[Bone Marrow - Anatomy & Physiology|bone marrow]] and migrate to the [[Thymus - Anatomy & Physiology|thymus]], and those destined to be [[B cells]] migrate to the [[Spleen - Anatomy & Physiology|spleen]] and gut-associated lymphoid tissue (GALT) or proliferate directly from the bone marrow.

{|cellpadding="5" cellspacing="1" border="1"  

{|cellpadding="5" cellspacing="1" border="1"  

|

|

|colspan="4"|CFU-L

|colspan="4"|CFU-L

|-align="center"

|-align="center"

|style="background-color:#ffffcc"|^{▼Il-7 & Il-11}

|style="background-color:#ffffcc"|^{▼IL-7 & IL-11}

|colspan="3" style="background-color:#e6e6fa"|^{▼Il-7 & SCF}

|colspan="3" style="background-color:#e6e6fa"|^{▼IL-7 & SCF}

|-align="center"

|-align="center"

|style="background-color:#ffffcc"|B lymphoid cell progenitor

|style="background-color:#ffffcc"|B lymphoid cell progenitor

|colspan="3" style="background-color:#e6e6fa"|T lymphoid cell progenitor

|colspan="3" style="background-color:#e6e6fa"|T lymphoid cell progenitor

|-align="center"

|-align="center"

|style="background-color:#ffffcc"|^{▼Il-3 & Il-7}

|style="background-color:#ffffcc"|^{▼IL-3 & IL-7}

|style="background-color:#e6e6fa"|^▼Il-7

|style="background-color:#e6e6fa"|^▼IL-7

|style="background-color:#e6e6fa"|^{▼Il-2, IL-12 & Il-18}

|style="background-color:#e6e6fa"|^{▼IL-2, IL-12 & IL-18}

|style="background-color:#e6e6fa"|^{▼Il-3, Il-6, GM-CSF & SCF}

|style="background-color:#e6e6fa"|^{▼IL-3, IL-6, GM-CSF & SCF}

|-align="center"

|-align="center"

|style="background-color:#ffffcc"|Pre-B cell

|style="background-color:#ffffcc"|Pre-B cell

|}

|}

<p>'''Note:'''

<p>'''Note:'''

*That between the 'pre-[type] cell' stage and the final mature all the lymphocytes are referred to as 'immature [type] cells'.  

*Between the 'pre-[type] cell' stage and the final mature all the lymphocytes are referred to as 'immature [type] cells'.  

* T cell differentiation into it's different forms (helper, cytotoxic and T cell with regulator functions) is under stimulation by Il-10 & TNF-γ</p>

* T cell differentiation into helper, cytotoxic and T cells with regulator functions is induced by IL-10 & TNF-γ

[[Category:Haematopoiesis]]

[[Category:Haematopoiesis]]