Changes

==B2 Integrin adhesion molecule deficiencies==

==B2 Integrin adhesion molecule deficiencies==

This leucocyte adhesion deficiency-1 (LAD-1) results in decreased adhesion, impaired chemotaxis and minimal bactericidal function. Monocyte activity is also impaired. Affected animals suffe from recurrent bacterial and fungal infections without purulent inflammation. There is frequently a peripheral neutrophila, +/- a left shift and monocytosis. This condition has been reported in Irish Setters and Holstein cattle.

This leucocyte adhesion deficiency-1 (LAD-1) results in decreased adhesion, impaired chemotaxis and minimal bactericidal function. Monocyte activity is also impaired. Affected animals suffe from recurrent bacterial and fungal infections without purulent inflammation. There is frequently a peripheral neutrophila, +/- a left shift and monocytosis. This condition has been reported in Irish Setters and Holstein cattle.

'''Storage diseases.''' Lysosomes are membrane bound vesicles, containing enzymes which are capable of degrading the majority of biologically important macromolecules. An inherited deficiency in anyone of these enzymes results in the accumulation of substrate within lysosomes; in type i/v mucopolysaccharidosis, for example, this may be evident as blue-magenta coloured granules within the neutrophils’ cytoplasm.

'''Storage diseases.''' Lysosomes are membrane bound vesicles, containing enzymes which are capable of degrading the majority of biologically important macromolecules. An inherited deficiency in anyone of these enzymes results in the accumulation of substrate within lysosomes; in type i/v mucopolysaccharidosis, for example, this may be evident as blue-magenta coloured granules within the neutrophils’ cytoplasm.

==Authors and References==

==Authors and References==

Inherited disorders of Leukocyts: [[NationWide Laboratories]]

[[NationWide Laboratories]]

 

[[Category:Haematology|7]]