Difference between revisions of "Pseudomonas aeruginosa"

Latest revision as of 17:52, 4 January 2023

Pseudomonas aerginosa
Phylum	Proteobacteria
Class	Gamma Proteobacteria
Order	Pseudomonadales
Family	Pseudomonadaceae
Genus	Pseudomonas
Species	P.aerginosa

microscopic image of Pseudomonas aeruginosa.(Y_tambe 2005, Wikimedia commons)

Overview

Pseudomonas aeruginosa is a species of the pseudomonas genus. It causes opportunistic infections requiring predisposing factors.

Pathogenesis

P.aeruginosa grows on few nutrients and can survive certain disinfectants. The bacteria has toxins and enzymes such as exotoxin A, phospholipase C and proteases that allow tissue invasion and damage. Elastase damages elastin in lung parenchyma and blood vessel walls. P.aeruginosa attaches to host cells via fimbrae and resists phagocytosis and complement via its LPS. It obtains iron from tissues.

Mink

P.aeruginosa causes haemorrhagic pneumonia and septicaemia in mink with 50% mortality via a secondary thrombocytopenic disease.

Cows

P.aeruginosa causes bovine mastitis associated with contaminated water used for washing udders; also metritis, pneumonia, dermatitis and enteritis in cattle.

Sheep

P.aeruginosa causes ovine fleece rot, also mastitis, pneumonia and otitis media.

Reptiles

P.aeruginosa causes necrotic stomatitis in captive reptiles.

Pigs

P.aeruginosa causes respiratory infections and otitis in pigs.

Horses

P.aeruginosa causes genital tract infections, pneumonia and ulcerative keratitis in horses.

Dogs and cats

P.aeruginosa causes otitis externa, cystitis, pneumonia and ulcerative keratitis in dogs and cats.

It can also cause deep pyoderma in all species.

Diagnosis

Specimens for diagnosis should include; pus, respiratory aspirates, mid-stream urine and ear swabs. Colonies can be identified on blood and MacConkey agar and are oxidative, not fermentative. The colonies only grow in aerobic conditions and produce diffusable pigments including pyocyanin, a green pigment, and fluorescine. On MacConkey agar, colonies have a fruity odour, are lactose negative and are pale in colour.

Treatment

P.aeruginosa bacteria have multiple antibiotic resistance, mediated by large plasmids carrying resistance genes and also chromosomal genes and mutations. Gentamicin or tobramycin with carbenicillin or ticarcillin, as well as polymyxin B are effective.

Pseudomonas aeruginosa Learning Resources
Literature Search Search for recent publications via CAB Abstract (CABI log in required)	Pseudomonas aeruginosa in mink publications Pseudomonas aeruginosa in cattle publications Pseudomonas aeruginosa in sheep publications Pseudomonas aeruginosa in reptiles publications Pseudomonas aeruginosa in pigs publications Pseudomonas aeruginosa in horses publications Pseudomonas aeruginosa in dogs and cats publications Pseudomonas aeruginosa publications since 2000

Webinars

Failed to load RSS feed from https://www.thewebinarvet.com/antimicrobial-resistance/webinars/feed: Error parsing XML for RSS

@@ Line 1: / Line 1: @@
-*Causes opportunistic infections requiring predisposing factors
-*Pathogenesis:
+{{Taxobox
-**Grows on few nutrients and can survive certain disinfectants
+|name               =''Pseudomonas aerginosa''
-**Toxins and enzymes such as exotoxin A, phospholipase C and proteases allow tissue invasion and damage
+|phylum             =Proteobacteria
-**Elastase damages elastin in lung parenchyma and blood vessel walls
+|class              =Gamma Proteobacteria
-**Attachment to host cells via fimbrae
+|order              =Pseudomonadales
-**Resists phagocytosis and complement via its LPS
+|family             =Pseudomonadaceae
-**Obtains iron from tissues
+|genus              =Pseudomonas
-*Clinical infections:
+|species            =''P.aerginosa''
-**Haemorrhagic pneumonia and septicaemia in mink with 50% mortality via a [[Haemostasis - Pathology#Secondary Thrombocytopenic Disease|secondary thrombocytopenic disease]]
+}}
-**Bovine mastitis associated with contaminated water used for washing udders; also metritis, pneumonia, dermatitis and enteritis in cattle
+[[File:Pseudomonas aer.jpg|right|thumb|250px|<small><center> microscopic image of ''Pseudomonas aeruginosa''.(Y_tambe
-**[[Bacterial skin infections - Pathology#Ovine fleece rot|Ovine fleece rot]] - suppurative dermatitis after penetration of water into fleece; wool discoloured by pyocyanin pigment; also mastitis, pneumonia, otitis media
+, Wikimedia commons)</center></small>]]
-**Necrotic stomatitis in captive reptiles
+==Overview==
-**Respiratory infections and otitis in pigs
+''Pseudomonas aeruginosa'' is a species of the ''[[Pseudomonas species - Overview|pseudomonas]]'' genus. It causes opportunistic infections requiring predisposing factors.
-**Genital tract infections, pneumonia, ulcerative keratitis in horses
-**Otitis externa, cystitis, pneumonia, ulcerative keratitis in dogs and cats
+==Pathogenesis==
-**Causes [[Bacterial skin infections - Pathology#Deep pyoderma|deep pyoderma]]
+''P.aeruginosa'' grows on few nutrients and can survive certain disinfectants. The bacteria has toxins and enzymes such as exotoxin A, phospholipase C and proteases that allow tissue invasion and damage. Elastase damages elastin in lung parenchyma and blood vessel walls. ''P.aeruginosa'' attaches to host cells via fimbrae and resists phagocytosis and complement via its LPS. It obtains iron from tissues.
-*Diagnosis:
-**Specimens should include pus, respiratory aspirates, mid-stream urine and ear swabs
+'''Mink'''
-**Identify colonies on blood and MacConkey agar
-**Oxidative not fermentative
+''P.aeruginosa'' causes haemorrhagic pneumonia and septicaemia in mink with 50% mortality via a [[Platelet Abnormalities|secondary thrombocytopenic disease]].
-**Only grow in aerobic conditions
-**Produces diffusable pigments including pyocyanin, a green pigment, and  fluorescine
+'''Cows'''
-**Grow on MacConkey agar; colonies have a fruity odour; lactose negative, pale colonies on MacConkey
-*Treatment:
+''P.aeruginosa'' causes [[Mastitis|bovine mastitis]] associated with contaminated water used for washing udders; also metritis, pneumonia, dermatitis and [[:Category:Intestine - Inflammatory Pathology|enteritis]] in cattle.
-**Multiple antibiotic resistance mediated by large plasmids carrying resistance genes and also chromosomal genes and mutations
-**Gentamicin or tobramycin with carbenicillin or ticarcillin, as well as polymyxin B are effective
+'''Sheep'''
+''P.aeruginosa'' causes [[Ovine Fleece Rot|ovine fleece rot]], also mastitis, pneumonia and otitis media.
+'''Reptiles'''
+''P.aeruginosa'' causes necrotic stomatitis in captive reptiles.
+'''Pigs'''
+''P.aeruginosa'' causes respiratory infections and otitis in pigs.
+'''Horses'''
+''P.aeruginosa'' causes genital tract infections, pneumonia and ulcerative keratitis in horses.
+'''Dogs and cats'''
+''P.aeruginosa'' causes [[Otitis Externa - Cat and Dog|otitis externa]], [[Cystitis|cystitis]], pneumonia and ulcerative keratitis in dogs and cats.
+It can also cause [[Bacterial skin infections - Pathology#Deep pyoderma|deep pyoderma]] in all species.
+==Diagnosis==
+Specimens for diagnosis should include; pus, respiratory aspirates, mid-stream urine and ear swabs. Colonies can be identified on blood and MacConkey agar and are oxidative, not fermentative. The colonies only grow in aerobic conditions and produce diffusable pigments including pyocyanin, a green pigment, and  fluorescine. On MacConkey agar, colonies have a fruity odour, are lactose negative and are pale in colour.
+==Treatment==
+''P.aeruginosa'' bacteria have multiple antibiotic resistance, mediated by large plasmids carrying resistance genes and also chromosomal genes and mutations. Gentamicin or tobramycin with carbenicillin or ticarcillin, as well as polymyxin B are effective.
+{{Learning
+|literature search = [http://www.cabdirect.org/search.html?q=title%3A%28%22Pseudomonas+aeruginosa%22%29+AND+od%3A%28Mink%29 ''Pseudomonas aeruginosa'' in mink publications]
+[http://www.cabdirect.org/search.html?q=title%3A%28%22Pseudomonas+aeruginosa%22%29+AND+od%3A%28cattle%29 ''Pseudomonas aeruginosa'' in cattle publications]
+[http://www.cabdirect.org/search.html?q=title%3A%28%22Pseudomonas+aeruginosa%22%29+AND+od%3A%28sheep%29 ''Pseudomonas aeruginosa'' in sheep publications]
+[http://www.cabdirect.org/search.html?q=%28%28title%3A%28%22Pseudomonas+aeruginosa%22%29+AND+up%3A%28reptiles%29%29%29+OR+%28%28title%3A%28%22Pseudomonas+aeruginosa%22%29+AND+od%3A%28reptiles%29%29%29 ''Pseudomonas aeruginosa'' in reptiles publications]
+[http://www.cabdirect.org/search.html?q=title%3A%28%22Pseudomonas+aeruginosa%22%29+AND+od%3A%28pigs%29  ''Pseudomonas aeruginosa'' in pigs publications]
+[http://www.cabdirect.org/search.html?q=title%3A%28%22Pseudomonas+aeruginosa%22%29+AND+od%3A%28horses%29 ''Pseudomonas aeruginosa'' in horses publications]
+[http://www.cabdirect.org/search.html?q=title%3A%28%22Pseudomonas+aeruginosa%22%29+AND+%28od%3A%28dogs%29+OR+od%3A%28cats%29%29 ''Pseudomonas aeruginosa'' in dogs and cats publications]
+[http://www.cabdirect.org/search.html?rowId=1&options1=AND&q1=%22Pseudomonas+aeruginosa%22&occuring1=title&rowId=2&options2=AND&q2=&occuring2=freetext&rowId=3&options3=AND&q3=&occuring3=freetext&publishedstart=2000&publishedend=yyyy&calendarInput=yyyy-mm-dd&la=any&it=any&show=all&x=31&y=4 ''Pseudomonas aeruginosa'' publications since 2000]
+}}
+{{review}}
+==Webinars==
+<rss max="10" highlight="none">https://www.thewebinarvet.com/antimicrobial-resistance/webinars/feed</rss>
 [[Category:Pseudomonas_and_Burkholderia_species]]
+[[Category:Expert_Review]]