Difference between revisions of "Peyer's Patches - Anatomy & Physiology"
Fiorecastro (talk | contribs) |
|||
| (28 intermediate revisions by 3 users not shown) | |||
| Line 1: | Line 1: | ||
| − | + | {{toplink | |
| + | |backcolour = f5fffa | ||
| + | |linkpage =Lymphoreticular & Haematopoietic System - Anatomy & Physiology | ||
| + | |linktext =LYMPHORETICULAR & HAEMATOPOIETIC SYSTEM (Ant & Phys) | ||
| + | |tablelink = Lymphoreticular & Haematopoietic System (Table)- Anatomy & Physiology | ||
| + | |maplink = Lymphoreticular & Haematopoietic System (Concept Map)- Anatomy & Physiology | ||
| + | |sublink1 =Primary Lymphoid Tissue - Anatomy & Physiology | ||
| + | |subtext1 =PRIMARY LYMPHOID TISSUE (Ant & Phys) | ||
| + | }} | ||
[[Image:LH Ileal Peyer's Patch Diagram.jpg|thumb|250px|right|<p>'''Diagram: Peyer's patch'''</p><sup>©Nottingham Uni 2008</sup>]] | [[Image:LH Ileal Peyer's Patch Diagram.jpg|thumb|250px|right|<p>'''Diagram: Peyer's patch'''</p><sup>©Nottingham Uni 2008</sup>]] | ||
| − | |||
<p>''Also called aggregated nodules''</p> | <p>''Also called aggregated nodules''</p> | ||
| − | <p>Peyer’s patches are lymphoid tissues found in the wall of the | + | <p>Peyer’s patches are lymphoid tissues found in the wall of the small intestine. They are part of the mucosal-associated lymphoid tissues (MALT) and more specifically the gut-associated lymphoid tissue (GALT). Although nodules of lymphatic tissue are found throughout the intestines in the small intestine larger collections of nodules exist and these are referred to as Peyer’s patches. In many species they act as a primary lymphoid tissue (cattle, sheep , pigs, horses, dogs and rabbits).</p> |
==Development == | ==Development == | ||
<p>In cattle, sheep , pigs, horses and dogs over eighty percent of the patches are found in the [[Ileum - Anatomy & Physiology|ileum]] where they form a continuous structure which is most developed before birth and regresses to the point that in the adult they cannot be detected. The rest of the patches are found in the [[jejunum - Anatomy & Physiology|jejunum]] and are isolated from each other, however these patches last throughout adult life.</p><p> In rabbits and rodents the patches are randomly located along both the [[Ileum - Anatomy & Physiology|ileum]] and [[jejunum - Anatomy & Physiology|jejunum]] and persist throughout life.</p> | <p>In cattle, sheep , pigs, horses and dogs over eighty percent of the patches are found in the [[Ileum - Anatomy & Physiology|ileum]] where they form a continuous structure which is most developed before birth and regresses to the point that in the adult they cannot be detected. The rest of the patches are found in the [[jejunum - Anatomy & Physiology|jejunum]] and are isolated from each other, however these patches last throughout adult life.</p><p> In rabbits and rodents the patches are randomly located along both the [[Ileum - Anatomy & Physiology|ileum]] and [[jejunum - Anatomy & Physiology|jejunum]] and persist throughout life.</p> | ||
==Structure== | ==Structure== | ||
| − | Peyer’s patches are located in the lamina propria and submucosa of | + | Peyer’s patches are located in the lamina propria and submucosa of small intestine and may be distinguishable by the lack of villi covering them. The patches are regions of concentrated [[Lymphocytes - Anatomy & Physiology#B cells|B lymphocyte]] follicles covered in a ‘dome’ of a specialised follicle associated epithelium (FAE) which consists of follicle associated enterocytes and M (microfold or multifold) cells. |
===M cells=== | ===M cells=== | ||
M cells transport antigens from the intestinal lumen to the lymphocytes. Their luminal surface is folded and takes up antigens from the intestine via endocytosis and transports them to the extracellular space on their basal surface where the antigen is processed by antigen presenting cells. | M cells transport antigens from the intestinal lumen to the lymphocytes. Their luminal surface is folded and takes up antigens from the intestine via endocytosis and transports them to the extracellular space on their basal surface where the antigen is processed by antigen presenting cells. | ||
| Line 18: | Line 25: | ||
==Function== | ==Function== | ||
| − | Peyer’s patches have a similar role to that of the avian [[Bursa of Fabricius - Anatomy & Physiology|bursa of Fabricius]] in maturing and differentiation immature B lymphocytes. Antigens are presented to the [[Lymphocytes#B cells|B lymphocytes]] in the follicle which causes the [[Lymphocytes#B cells|B cells]] to become committed to | + | Peyer’s patches have a similar role to that of the avian [[Bursa of Fabricius - Anatomy & Physiology|bursa of Fabricius]] in maturing and differentiation immature B lymphocytes. Antigens are presented to the [[Lymphocytes - Anatomy & Physiology#B cells|B lymphocytes]] in the follicle which causes the [[Lymphocytes - Anatomy & Physiology#B cells|B cells]] to become committed to IgA synthesis. |
| − | |||
==In pathology== | ==In pathology== | ||
| − | *[[Salmonellosis|Septicaemic | + | *For specific pathology see [[Lymphoreticular/Haemotopoietic System - Ileal Peyer's Patch# Pathology|here]] |
| − | *[[ | + | *[[Intestines - Fibrinous/ Haemorrhagic Enteritis#Septicaemic Salmonellosis|Septicaemic almonellosis]] affects the Peyer's patches |
| − | *Infected by mycobacteria in [[ | + | *[[Oral Cavity - Cavity & Gingiva#Erosive & Ulcerative Pathology|Bovine Viral Diarrhoea disease]] causes ulcers to form over the patches |
| − | + | *Infected by mycobacteria in [[Intestines - Proliferative Enteritis#Paratuberculosis (Johnes disease)|Johnes disease]] | |
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
| − | |||
Revision as of 16:20, 18 July 2008
|
|
Also called aggregated nodules
Peyer’s patches are lymphoid tissues found in the wall of the small intestine. They are part of the mucosal-associated lymphoid tissues (MALT) and more specifically the gut-associated lymphoid tissue (GALT). Although nodules of lymphatic tissue are found throughout the intestines in the small intestine larger collections of nodules exist and these are referred to as Peyer’s patches. In many species they act as a primary lymphoid tissue (cattle, sheep , pigs, horses, dogs and rabbits).
Development
In cattle, sheep , pigs, horses and dogs over eighty percent of the patches are found in the ileum where they form a continuous structure which is most developed before birth and regresses to the point that in the adult they cannot be detected. The rest of the patches are found in the jejunum and are isolated from each other, however these patches last throughout adult life.
In rabbits and rodents the patches are randomly located along both the ileum and jejunum and persist throughout life.
Structure
Peyer’s patches are located in the lamina propria and submucosa of small intestine and may be distinguishable by the lack of villi covering them. The patches are regions of concentrated B lymphocyte follicles covered in a ‘dome’ of a specialised follicle associated epithelium (FAE) which consists of follicle associated enterocytes and M (microfold or multifold) cells.
M cells
M cells transport antigens from the intestinal lumen to the lymphocytes. Their luminal surface is folded and takes up antigens from the intestine via endocytosis and transports them to the extracellular space on their basal surface where the antigen is processed by antigen presenting cells.
Histology
Intetsine w/Peyer's patch
©RVC 2008
Peyer's patch
©RVC 2008
Peyer's patches
Courtesy of BioMed Archive
Function
Peyer’s patches have a similar role to that of the avian bursa of Fabricius in maturing and differentiation immature B lymphocytes. Antigens are presented to the B lymphocytes in the follicle which causes the B cells to become committed to IgA synthesis.
In pathology
- For specific pathology see here
- Septicaemic almonellosis affects the Peyer's patches
- Bovine Viral Diarrhoea disease causes ulcers to form over the patches
- Infected by mycobacteria in Johnes disease