Difference between revisions of "Testicular Feminisation"

Revision as of 13:37, 3 September 2008

Genotype XY as should be in the male.
Testes develop normally and secrete Androgens and MIH
Foetal genetalia are genetically insensitive to the actions of Androgens due to a point mutation in the Androgen receptor.

Wolffian Ducts regress, allowing formation of female external genetalia:
- Labia
- Clitoris
- Vagina
Sertoli cells are present and continue to secrete MIH, causing Mullarian Duct regression.
Since both Wolffian AND Mullarian Ducts regress, there is no internal genetalia.

@@ Line 1: / Line 1: @@
-#redirect[[Intersex#Testicular feminisation]]
+{{toplink
+|backcolour =EED2EE
+|linkpage =Reproductive System - Anatomy & Physiology
+|linktext =Reproductive System
+|maplink = Reproductive System (Content Map) - Anatomy & Physiology
+|pagetype =Anatomy
+|sublink1=Reproductive System - Anatomy & Physiology#Fertilisation.2C Implantation and Early Embryonic Development
+|subtext1=FERTILISATION , IMPLANTATION AND EARLY EMBRYONIC DEVELOPMENT
+|sublink2=Fertilisation, Implantation and Early Embryonic Development -Sexual Differentiation- Anatomy & Physiology
+|subtext2=SEXUAL DIFFERENTIATION
+}}
+<br>
+== Aetiology ==
+* Genotype XY as should be in the male.
+* Testes develop normally and secrete Androgens and MIH
+* Foetal genetalia are genetically insensitive to the actions of Androgens due to a point mutation in the Androgen receptor.
+== Consequence ==
+* Wolffian Ducts regress, allowing formation of '''female external genetalia''':
+** Labia
+** Clitoris
+** Vagina
+* Sertoli cells are present and continue to secrete MIH, causing Mullarian Duct regression.
+* Since both Wolffian AND Mullarian Ducts regress, there is '''no internal genetalia'''.