Difference between revisions of "Fungi"
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| + | {{toplink | ||
| + | |backcolour = FFE4E1 | ||
| + | |linkpage =Immunology - WikiBlood | ||
| + | |linktext =IMMUNOLOGY | ||
| + | |sublink1 =Host invasion by microorganisms - WikiBlood | ||
| + | |subtext1 =HOST INVASION BY MICROORGANISMS | ||
| + | |sublink2 =Fungi | ||
| + | |subtext2 =INFECTIOUS AGENTS AND PARASITES | ||
| + | |pagetype =Blood | ||
| + | }} | ||
| + | =Introduction= | ||
| − | + | Although there are over 50,000 identified species of fungi, only a few hundred are known to be pathogenic, causing infections known as mycoses (mycology being the study of fungi). Fungi are nonphotosynthetic organisms with a eukaryotic cell structure and are able to grow as branching or filamentous forms (mycelia) or as single cells (yeasts). | |
| + | |||
| + | =Major pathogenic fungi= | ||
| + | '''Superficial''': These infections affect only the skin, hair, nails etc. | ||
| + | *Generally not dangerous | ||
| + | *Examples- ''Hortaea werneckii'', causing tinea nigra, and ''Piedraia hortae'', causing black piedra | ||
| + | |||
| + | '''Cutaneous''': Also known as '''dermatophytoses''' | ||
| + | *Only affect superficial keratinized tissue- skin, hair and nails | ||
| + | *Again generally not dangerous | ||
| + | *Examples- ''Candida albicans'', causing candidiasis of the skin and nails, ''Microsporum'' species | ||
| + | |||
| + | '''Subcutaneous''': Usually cause chronic localised infections of the skin and underlying dermis | ||
| + | *Normally reside in soil and vegetation; they enter skin through cuts and grazes | ||
| + | *Can occasionally affect the deep tissues, e.g. bones and muscles | ||
| + | *Examples- ''Sporothrix schenkii'', causing sporotrichosis, ''Madurella mycetomatis'' causing mycetoma | ||
| + | |||
| + | '''Systemic''': Also known as '''deep''', '''endemic''' or '''primary''' | ||
| + | *Usually serious; sometimes fatal | ||
| + | *Examples- ''Histoplasma capsulatum'' causing histoplasmosis, ''Blastomyces dermatitidis'' causing blastomycosis | ||
| + | |||
| + | '''Opportunistic''': Ubiquitous fungi that affect only susceptible hosts; immunocompetent individuals are normally resistant | ||
| + | *Examples- ''Aspergillus fumigatus'', causing aspergilliosis, ''Cryptococcus neoformans'', causing cryptococcosis | ||
| + | |||
| + | =Immunity to fungi= | ||
| + | Cutaneous and superficial fungal infections are normally self-limiting, with recovery associated with a resistance to re-infection. As hosts often develop delayed-type hypersensitivity, this resistance appears to be cell-mediated. | ||
| + | *T cell immunity- it is thought that helper T cells release cytokines to activate macrophages to fight the infection | ||
| + | *Neutrophils- there is now growing evidence for the role of neutrophils in some infections of the respiratory system, with defensin and the nitric oxide pathways implicated | ||
Revision as of 12:44, 4 September 2008
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Introduction
Although there are over 50,000 identified species of fungi, only a few hundred are known to be pathogenic, causing infections known as mycoses (mycology being the study of fungi). Fungi are nonphotosynthetic organisms with a eukaryotic cell structure and are able to grow as branching or filamentous forms (mycelia) or as single cells (yeasts).
Major pathogenic fungi
Superficial: These infections affect only the skin, hair, nails etc.
- Generally not dangerous
- Examples- Hortaea werneckii, causing tinea nigra, and Piedraia hortae, causing black piedra
Cutaneous: Also known as dermatophytoses
- Only affect superficial keratinized tissue- skin, hair and nails
- Again generally not dangerous
- Examples- Candida albicans, causing candidiasis of the skin and nails, Microsporum species
Subcutaneous: Usually cause chronic localised infections of the skin and underlying dermis
- Normally reside in soil and vegetation; they enter skin through cuts and grazes
- Can occasionally affect the deep tissues, e.g. bones and muscles
- Examples- Sporothrix schenkii, causing sporotrichosis, Madurella mycetomatis causing mycetoma
Systemic: Also known as deep, endemic or primary
- Usually serious; sometimes fatal
- Examples- Histoplasma capsulatum causing histoplasmosis, Blastomyces dermatitidis causing blastomycosis
Opportunistic: Ubiquitous fungi that affect only susceptible hosts; immunocompetent individuals are normally resistant
- Examples- Aspergillus fumigatus, causing aspergilliosis, Cryptococcus neoformans, causing cryptococcosis
Immunity to fungi
Cutaneous and superficial fungal infections are normally self-limiting, with recovery associated with a resistance to re-infection. As hosts often develop delayed-type hypersensitivity, this resistance appears to be cell-mediated.
- T cell immunity- it is thought that helper T cells release cytokines to activate macrophages to fight the infection
- Neutrophils- there is now growing evidence for the role of neutrophils in some infections of the respiratory system, with defensin and the nitric oxide pathways implicated