Difference between revisions of "Complement Flashcards"

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(New page: {{toplink |backcolour = FFE4E1 |linkpage =Complement - WikiBlood |linktext =COMPLEMENT |sublink1 =Flash Cards - WikiBlood |subtext1 =WIKIBLOOD FLASHCARDS |pagetype =Blood }} ==<font color...)
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===Complement Fixation Pathways===
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{{toplink
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<FlashCard questions="10">
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|backcolour = FFE4E1
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|q1=What are the names of the different pathways of the complement cascade?
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|linkpage =Complement - WikiBlood
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|a1=
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|linktext =COMPLEMENT
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*Classical
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|sublink1 =Flash Cards - WikiBlood
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*Alternative
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|subtext1 =WIKIBLOOD FLASHCARDS
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*Mannose-binding Lectin
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|pagetype =Blood
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|l1=Complement#Compelment Fixation Pathways
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}}
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|q2=Which immunoglobulins can activate the classical pathway?
 
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|a2=
 
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*IgM
 
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*IgG
 
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|l2=Complement#Compelment Fixation Pathways
 
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|q3=What are the components of the C1 complex
 
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|a3=
 
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*C1q
 
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*C1r
 
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*C1s
 
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|l3=Complement#Compelment Fixation Pathways
 
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|q4=Which two complexes bind to make the enzyme C3 convertase?
 
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|a4=
 
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*C2a
 
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*C4b
 
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|l4=Complement#Compelment Fixation Pathways
 
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|q5=What initiates the membrane attack complex (MAC)?
 
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|a5=C3b
 
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|l5=Complement#Compelment Fixation Pathways
 
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|q6=What functions do the C fragments C3a, C4a, C5a and C2b have?
 
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|a6=
 
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*Chemotactic for neutrophils
 
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*Induces acute inflammation
 
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*Increases vascular permeability
 
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*Causes mast cell and basophil degranulation
 
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|l6=Complement#Compelment Fixation Pathways
 
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|q7=What are efficient activators of the alternative pathway?
 
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|a7=
 
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*Gram-negative bacteria
 
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*Yeasts
 
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*Fungi
 
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|l7=Complement#Alternative Pathway
 
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|q8=What are the main functions of the alternative pathway?
 
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|a8=
 
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*To coat bacteria with iC3b
 
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*To induce an acute inflammatory response
 
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|l8=Complement#Alternative Pathway
 
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|q9=What are lectins?
 
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|a9=Proteins which bind carbohydrates
 
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|l9=Complement#MB-Lectin Pathway
 
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|q10=What does MASP stand for?
 
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|a10=Mannose-binding lectin associated proteases
 
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|l10=Complement#MB-Lectin Pathway
 
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</FlashCard>
 
  
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===Complement Inhibitors===
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==<font color="purple">Complement Fixation Pathways</font>==
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<FlashCard questions="4">
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{| border="3" cellpadding="8"
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|q1=Which complement inhibitor exorts control over the classical pathway and how does it function?
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!width="400"|'''Question'''
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|a1=
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!width="400"|'''Answer'''
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*Delay acclerating factor (DAF)
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!width="150"|'''Article'''
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**Increases the degredation of C1 esterase
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|-
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|l1=Complement#Complement Inhibitors
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|<big>'''What are the names of the different pathways of the complement cascade?'''
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|q2=What do factors I and H do?
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||<font color="white"> <big>
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|a2=
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*'''''Classical'''''
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*Breaks down C3b
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*'''''Alternative'''''
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*Controls positive feedback by inhibiting C3b¯Bb
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*'''''Mannose-binding Lectin'''''
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*Prevents the complement cascade from running to exhaustion every time it is activated
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||[[Complement - WikiBlood#Compelment Fixation Pathways|<span title="Answer article">Link to Answer Article</span>]]
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|l2=Complement#Complement Inhibitors
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|-
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|q3=Which complement inhibitor binds inflammatory immune complexes in the plasma, transporting them to the liver for phagocytosis?
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|<big>'''Which immunoglobulins can activate the classical pathway?'''
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|a3=Complement receptor 1 (CR1)
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||<font color="white"> <big>
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|l3=Complement#Complement Inhibitors
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*'''''IgM'''''
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|q4=What does CD59 do?
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*'''''IgG'''''
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|a4=
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||[[Complement - WikiBlood#Compelment Fixation Pathways|<span title="Answer article">Link to Answer Article</span>]]
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*Prevents cell lysis and pore formation
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|-
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*It is a protective mechanism for cells
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|<big>'''What are the components of the C1 complex'''
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|l4=Complement#Complement Inhibitors
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||<font color="white"> <big>
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</FlashCard>
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*'''''C1q'''''
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===Functions of the Complement Cascade===
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*'''''C1r'''''
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<FlashCard questions="3">
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*'''''C1s'''''
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|q1=What are the stages of opsonisation?
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||[[Complement - WikiBlood#Compelment Fixation Pathways|<span title="Answer article">Link to Answer Article</span>]]
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|a1=
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|-
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*The complement system deposits a shell of protein on the bacterial cell surface, e.g. complement fragments
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|<big>'''Which two complexes bind to make the enzyme C3 convertase?'''
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*Complement fragments released are chemotactic for phagocytes
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||<font color="white"> <big>
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*iC3b acts as a target for phagocytosis
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*'''''C2b'''''
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*Phagocytes bind with the complement fragments destroying the bacteria
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*'''''C4b'''''
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|l1=Complement#Functions
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||[[Complement - WikiBlood#Compelment Fixation Pathways|<span title="Answer article">Link to Answer Article</span>]]
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|q2=What role do complement fragments have to promote inflammation?
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|-
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|a2=
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|<big>'''What initiates the membrane attack complex (MAC)?'''
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*Smaller complement fragments attract granulocytes to the site of inflammation
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||<font color="white"> <big>
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*Smaller complement fragments stimulate the degranulation of granulocytes
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*'''''C3b'''''
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|l2=Complement#Functions
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||[[Complement - WikiBlood#Compelment Fixation Pathways|<span title="Answer article">Link to Answer Article</span>]]
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|q3=By which process can C5-C9 directly kill pathogens?
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|-
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|a3=Cell lysis
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|<big>'''What functions do the Ca fragments have?'''
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|l3=Complement#Functions
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||<font color="white"> <big>
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</FlashCard>
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*'''''Chemotactic for neutrophils'''''
 +
*'''''Induces acute inflammation'''''
 +
*'''''Increases vascular permeability'''''
 +
*'''''Causes mast cell and basophil degranulation'''''
 +
||[[Complement - WikiBlood#Compelment Fixation Pathways|<span title="Answer article">Link to Answer Article</span>]]
 +
|-
 +
|<big>'''What are efficient activators of the alternative pathway?'''
 +
||<font color="white"> <big>
 +
*'''''Gram-negative bacteria'''''
 +
*'''''Yeasts'''''
 +
*'''''Fungi'''''
 +
||[[Complement - WikiBlood#Alternative Pathway|<span title="Answer article">Link to Answer Article</span>]]
 +
|-
 +
|<big>'''What are the main functions of the alternative pathway?'''
 +
||<font color="white"> <big>
 +
*'''''To coat bacteria with iC3b'''''
 +
*'''''To induce an acute inflammatory response'''''
 +
||[[Complement - WikiBlood#Alternative Pathway|<span title="Answer article">Link to Answer Article</span>]]
 +
|-
 +
|<big>'''What are lectins?'''
 +
||<font color="white"> <big>
 +
*'''''Proteins which bind carbohydrates'''''
 +
||[[Complement - WikiBlood#MB-Lectin Pathway|<span title="Answer article">Link to Answer Article</span>]]
 +
|-
 +
|<big>'''What does MASP stand for?'''
 +
||<font color="white"> <big>
 +
*'''''Mannose-binding lectin associated proteases'''''
 +
||[[Complement - WikiBlood#MB-Lectin Pathway|<span title="Answer article">Link to Answer Article</span>]]
 +
|}
 +
<br>
 +
<br>
 +
==<font color="purple">Complement Inhibitors</font>==
 +
{| border="3" cellpadding="8"
 +
!width="400"|'''Question'''
 +
!width="400"|'''Answer'''
 +
!width="150"|'''Article'''
 +
|-
 +
|<big>'''Which complement inhibitor exorts control over the classical pathway and how does it function?'''
 +
||<font color="white"> <big>
 +
*'''''Delay acclerating factor (DAF)'''''
 +
**'''''Increases the degredation of C1 esterase'''''
 +
||[[Complement - WikiBlood#Complement Inhibitors|<span title="Answer article">Link to Answer Article</span>]]
 +
|-
 +
|<big>'''What do factors I and H do?'''
 +
||<font color="white"> <big>
 +
*'''''Breaks down C3b'''''
 +
*'''''Controls positive feedback by inhibiting C3b¯Bb'''''
 +
*'''''Prevents the complement cascade from running to exhaustion every time it is activated'''''
 +
||[[Complement - WikiBlood#Complement Inhibitors|<span title="Answer article">Link to Answer Article</span>]]
 +
|-
 +
|<big>'''Which complement inhibitor binds inflammatory immune complexes in the plasma, transporting them to the liver for phagocytosis?'''
 +
||<font color="white"> <big>
 +
*'''''Complement receptor 1 (CR1)'''''
 +
||[[Complement - WikiBlood#Complement Inhibitors|<span title="Answer article">Link to Answer Article</span>]]
 +
|-
 +
|<big>'''What does CD59 do?'''
 +
||<font color="white"> <big>
 +
*'''''Prevents cell lysis and pore formation'''''
 +
*'''''It is a protective mechanism for cells'''''
 +
||[[Complement - WikiBlood#Complement Inhibitors|<span title="Answer article">Link to Answer Article</span>]]
 +
|}
 +
<br>
 +
<br>
  
−
<br><br>
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==<font color="purple">Functions of the Complement Cascade</font>==
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{{Jim Bee 2007}}
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{| border="3" cellpadding="8"
−
[[Category:Immunology Flashcards]]
+
!width="400"|'''Question'''
 +
!width="400"|'''Answer'''
 +
!width="150"|'''Article'''
 +
|-
 +
|<big>'''What are the stages of opsonisation?'''
 +
||<font color="white"> <big>
 +
*'''''The complement system deposits a shell of protein on the bacterial cell surface, e.g. complement fragments'''''
 +
*'''''Complement fragments released are chemotactic for phagocytes'''''
 +
*'''''iC3b acts as a target for phagocytosis'''''
 +
*'''''Phagocytes bind with the complement fragments destroying the bacteria'''''
 +
||[[Complement - WikiBlood#Functions|<span title="Answer article">Link to Answer Article</span>]]
 +
|-
 +
|<big>'''What role do complement fragments have to promote inflammation?'''
 +
||<font color="white"> <big>
 +
*'''''Smaller complement fragments attract granulocytes to the site of inflammation'''''
 +
*'''''Smaller complement fragments stimulate the degranulation of granulocytes'''''
 +
||[[Complement - WikiBlood#Functions|<span title="Answer article">Link to Answer Article</span>]]
 +
|-
 +
|<big>'''By which process can C5-C9 directly kill pathogens?'''
 +
||<font color="white"> <big>
 +
*'''''Cell lysis'''''
 +
||[[Complement - WikiBlood#Functions|<span title="Answer article">Link to Answer Article</span>]]
 +
|}
 +
<br>
 +
<br>

Revision as of 15:22, 5 September 2008

WikiBloodWikiBlood Banner.png
COMPLEMENT
WIKIBLOOD FLASHCARDS


Complement Fixation Pathways

Question Answer Article
What are the names of the different pathways of the complement cascade?
  • Classical
  • Alternative
  • Mannose-binding Lectin
 Link to Answer Article
Which immunoglobulins can activate the classical pathway?
  • IgM
  • IgG
 Link to Answer Article
What are the components of the C1 complex
  • C1q
  • C1r
  • C1s
 Link to Answer Article
Which two complexes bind to make the enzyme C3 convertase?
  • C2b
  • C4b
 Link to Answer Article
What initiates the membrane attack complex (MAC)?
  • C3b
 Link to Answer Article
What functions do the Ca fragments have?
  • Chemotactic for neutrophils
  • Induces acute inflammation
  • Increases vascular permeability
  • Causes mast cell and basophil degranulation
 Link to Answer Article
What are efficient activators of the alternative pathway?
  • Gram-negative bacteria
  • Yeasts
  • Fungi
 Link to Answer Article
What are the main functions of the alternative pathway?
  • To coat bacteria with iC3b
  • To induce an acute inflammatory response
 Link to Answer Article
What are lectins?
  • Proteins which bind carbohydrates
 Link to Answer Article
What does MASP stand for?
  • Mannose-binding lectin associated proteases
 Link to Answer Article



Complement Inhibitors

Question Answer Article
Which complement inhibitor exorts control over the classical pathway and how does it function?
  • Delay acclerating factor (DAF)
    • Increases the degredation of C1 esterase
 Link to Answer Article
What do factors I and H do?
  • Breaks down C3b
  • Controls positive feedback by inhibiting C3b¯Bb
  • Prevents the complement cascade from running to exhaustion every time it is activated
 Link to Answer Article
Which complement inhibitor binds inflammatory immune complexes in the plasma, transporting them to the liver for phagocytosis?
  • Complement receptor 1 (CR1)
 Link to Answer Article
What does CD59 do?
  • Prevents cell lysis and pore formation
  • It is a protective mechanism for cells
 Link to Answer Article



Functions of the Complement Cascade

Question Answer Article
What are the stages of opsonisation?
  • The complement system deposits a shell of protein on the bacterial cell surface, e.g. complement fragments
  • Complement fragments released are chemotactic for phagocytes
  • iC3b acts as a target for phagocytosis
  • Phagocytes bind with the complement fragments destroying the bacteria
 Link to Answer Article
What role do complement fragments have to promote inflammation?
  • Smaller complement fragments attract granulocytes to the site of inflammation
  • Smaller complement fragments stimulate the degranulation of granulocytes
 Link to Answer Article
By which process can C5-C9 directly kill pathogens?
  • Cell lysis
 Link to Answer Article



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