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T cell differentiation (view source)
Revision as of 12:59, 9 September 2008
, 12:59, 9 September 2008→T-Cell Activation
*** A major mechanism of tolerance.
*** A major mechanism of tolerance.
*** Ensures that T-cells do not react with self (non-dangerous) antigens.
*** Ensures that T-cells do not react with self (non-dangerous) antigens.
===TCR Complex===
[[Image:TCR Complex.jpg|thumb|right|150px|TCR Complex - Copyright Prof Dirk Werling DrMedVet PhD MRCVS]]
*The TCR is always associated with CD3
**The TCR and CD3 molecule is referred to as the '''TCR complex'''
*TCR is expressed on the surface of T cells in noncovalent association with a complex of transmembrane polypeptides
*CD3 contains 3 distinct polypeptide chains:
**γ, ε, and δ
**Members of the Ig superfamily
**The ε chain associates with both γ and δ
**'''chaperone''' role in transporting newly synthesized TCR molecules to the cell surface
**Expressed exclusively on T cells
*CD3 also contains 2 identical chains:
**ζ
**16 kDa
**Found on T cells, macrophages and NK cells
**Mice also can have an ε (eta) form
===Response to Activation===
===Response to Activation===