Changes

*Oropharyngeal infection followed by '''viremia'''

*Oropharyngeal infection followed by '''viremia'''

*2 distinct syndromes:

*2 distinct syndromes:

*#'''Myocarditis''' in puppies aged 3-8 weeks

#'''Myocarditis''' in puppies aged 3-8 weeks

***Virus targets rapidly dividing myocardium

#*Virus targets rapidly dividing myocardium

***Sudden death, '''fading puppy''' syndrome

#*Sudden death, '''fading puppy''' syndrome

***Now rare due to widespread passive immunity

#*Now rare due to widespread passive immunity

*#'''Enteritis''' in puppies >8 weeks of age

#'''Enteritis''' in puppies >8 weeks of age

***Virus targets intestinal crypts

#*Virus targets intestinal crypts

***Villi shorten, then destruction of cypt cells

#*Villi shorten, then destruction of cypt cells

***Gray, persistent, foul-smelling diarrhoea or hemorrhagic enteritis

#*Gray, persistent, foul-smelling diarrhoea or hemorrhagic enteritis

***High morbidity, low mortality (10%)

#*High morbidity, low mortality (10%)

====Epidemiology====

====Epidemiology====