Difference between revisions of "Papomaviridae"
Jump to navigation
Jump to search
(Redirected page to Category:Papillomaviridae) |
(New page: {{unfinished}} {{toplink |linkpage =Viruses |linktext =VIRUSES |pagetype =Bugs }} <br> =Introduction= Papillomaviruses infect keratinized cells, giving rise to sarcoids, warts, and papil...) |
||
| (One intermediate revision by the same user not shown) | |||
| Line 1: | Line 1: | ||
| − | # | + | {{unfinished}} |
| + | |||
| + | {{toplink | ||
| + | |linkpage =Viruses | ||
| + | |linktext =VIRUSES | ||
| + | |pagetype =Bugs | ||
| + | }} | ||
| + | <br> | ||
| + | |||
| + | =Introduction= | ||
| + | Papillomaviruses infect keratinized cells, giving rise to sarcoids, warts, and papillomas. | ||
| + | |||
| + | =Morphology= | ||
| + | *Medium-sized, icosahedral, non-enveloped dsDNA viruses | ||
| + | |||
| + | =Virulence and Pathogenesis= | ||
| + | *Target actively-dividing cells | ||
| + | *Warts: genes expressed are associated with '''transformation''' (hyperplasia and delayed maturation) | ||
| + | *Virus is shed as cells exfoliate | ||
| + | *Oral papillomas in young animals often resolve spontaneously | ||
| + | |||
| + | =Epidemiology= | ||
| + | *'''Resistant''' viruses: can persist in environment for months | ||
| + | *Restricted to stratified squamous and mucosal epithelia with slow growth | ||
| + | *Usually species specific | ||
| + | |||
| + | =Types and Subtypes= | ||
| + | |||
| + | |||
| + | =Virus by Species= | ||
| + | ===Canine Papillomavirus=== | ||
| + | *Occur in oropharynx of puppies aged 4-6 weeks | ||
| + | *Usually resolve spontaneously | ||
| + | |||
| + | ===Bovine Papillomaviruses=== | ||
| + | *2 groups: | ||
| + | #Fibropapillomas: viral DNA sequences, but no virus found | ||
| + | #Epithelial Papillomas: virus found | ||
| + | *Calves most commonly affected | ||
| + | *Usually resolves spontaneously | ||
| + | *Can undergo malignant transformation to alimentary carcinomas | ||
| + | **Usually concurrent with grazing bracken (co-carcinogen) and ingesting quercetin (immunosuppressant) | ||
| + | *Can cause squamous cell carcinoma of the eye in Hereford cattle, where UV light acts as the co-carcinogen | ||
| + | |||
| + | ===Equine Papillomaviruses=== | ||
| + | *Occurs in horses aged 1-3 years | ||
| + | *Muzzle, oral cavity | ||
| + | *Spread by direct contact | ||
| + | *Virus persists giving life long immunity and antibody-detection | ||
| + | *Usually resolves spontaneously but can be treated by laser or cryo-freezing | ||
| + | |||
| + | ===Equine Sarcoids=== | ||
| + | *Most common '''untreatable tumor''' | ||
| + | *Locally aggressive tumor of integument | ||
| + | *Associated with Arabs and Thoroughbreds | ||
| + | *Thought to be associated with '''bovine papillomaviruses''' | ||
| + | *Virus entry through skin abrasions | ||
| + | *Flies may act as mechanical vectors | ||
Revision as of 22:13, 30 October 2008
 |
This article is still under construction. |
|
Introduction
Papillomaviruses infect keratinized cells, giving rise to sarcoids, warts, and papillomas.
Morphology
- Medium-sized, icosahedral, non-enveloped dsDNA viruses
Virulence and Pathogenesis
- Target actively-dividing cells
- Warts: genes expressed are associated with transformation (hyperplasia and delayed maturation)
- Virus is shed as cells exfoliate
- Oral papillomas in young animals often resolve spontaneously
Epidemiology
- Resistant viruses: can persist in environment for months
- Restricted to stratified squamous and mucosal epithelia with slow growth
- Usually species specific
Types and Subtypes
Virus by Species
Canine Papillomavirus
- Occur in oropharynx of puppies aged 4-6 weeks
- Usually resolve spontaneously
Bovine Papillomaviruses
- 2 groups:
- Fibropapillomas: viral DNA sequences, but no virus found
- Epithelial Papillomas: virus found
- Calves most commonly affected
- Usually resolves spontaneously
- Can undergo malignant transformation to alimentary carcinomas
- Usually concurrent with grazing bracken (co-carcinogen) and ingesting quercetin (immunosuppressant)
- Can cause squamous cell carcinoma of the eye in Hereford cattle, where UV light acts as the co-carcinogen
Equine Papillomaviruses
- Occurs in horses aged 1-3 years
- Muzzle, oral cavity
- Spread by direct contact
- Virus persists giving life long immunity and antibody-detection
- Usually resolves spontaneously but can be treated by laser or cryo-freezing
Equine Sarcoids
- Most common untreatable tumor
- Locally aggressive tumor of integument
- Associated with Arabs and Thoroughbreds
- Thought to be associated with bovine papillomaviruses
- Virus entry through skin abrasions
- Flies may act as mechanical vectors