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|pagetype = Drugs
|pagetype = Drugs
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Gastroprotective drugs are often used for the following reasons:
* Gastric and duodenal ulceration
* Gastritis
* Reflux Oesphagitis
* Rumenal Acidosis
They following are the different classes of drugs that are used as gastroprotectives.
==Antacids==
==Antacids==
==Binding Agents==
==Binding Agents==
An is example is '''sucralfate''' that is administered orally.
It works by forming a viscous paste in an acidic environment, the binds and protects the mucosal surface. It also stimulates mucus and bicarbonate secretion and the production of prostaglandins.
==Prostaglandin E Analogues==
An example is '''misoprostol''' that is administered orally.
It works by mimicing the endogenously produced prostaglandins that are gastroprotective. This will therefore inhibit H<sup>+</sup> production and increase mucus and bicarbonate production. It will also maintain normal mucosal blood flow.
It should be used when Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) are being used, as NSAIDs block prostoglandin formation and so the gastric lining will be more prone to damage.