Difference between revisions of "Butyrophenones"

Revision as of 15:01, 3 March 2009

Butyrophenones are sedative drugs, which have a potent anti-emetic effect.

Butyrophenones antagonise dopamine transmission in the CNS.

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 ==Side Effects and Contraindications==
-Adverse effects in the CNS may occur, for example hallucinations and agitation have been reported in man. Vasodilation and hypotension also result from administration.
 ==Drugs in this Group==
-* [[#Azaperone|Azaperone]]
-* Fluanisone
-* Droperidol
-===Azaperone===
-Azaperone is marketed under the trade name of Stresnil. It modifies behaviour and gives dose-related sedation. It is used in pigs, for example against aggresssion and transport stress, to aid obstetrical intervention and as a premedicant. Intramuscular administration is preferred, with a 20 minute onset time (this is 5 mins if given i/v). The effects last 2-6 hours, and the drug potentiates anaesthetic agents.
-[[Category:Sedatives and Tranquilisers]]