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Exocrine Pancreatic Insufficiency (view source)
Revision as of 11:24, 7 August 2009
, 11:24, 7 August 2009no edit summary
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<big><center>[[Pancreas Developmental - Pathology|'''BACK TO PANCREAS - DEVELOPMENTAL''']]</center></big>
<big><center>[[Pancreas Degenerative - Pathology|'''BACK TO PANCREAS - DEGENERATIVE''']]</center></big>
<big><center>[[Pancreas Inflammatory - Pathology|'''BACK TO PANCREAS - INFLAMMATORY''']]</center></big>
<big><center>[[Pancreas Hyperplastic and Neoplastic - Pathology|'''BACK TO PANCREAS - HYPERPLASTIC AND NEOPLASTIC''']]</center></big>
*'''Exocrine pancreatic insufficiency (EPI)''' is a syndrome caused by insufficient synthesis and secretion of digestive enzymes by the exocrine portion of the pancreas
*Leading to insufficient activity of digestive enzymes in the lumen of the small intestine
*Pancreas has considerable functional reserve, large proportion needs to be non-functional to show signs of EPI
*Most common in dog - usually associated with [[Pancreas Degenerative - Pathology|pancreatic atrophy]] or [[Pancreas Inflammatory - Pathology#Chronic Pancreatitis|chronic pancreatitis]]
*Occurs occasionally in other species, esp. calves with [[Pancreas Developmental - Pathology#Pancreatic hypoplasia|pancreatic hypoplasia]] and in cats
*'''Clinical signs'''
**Steatorrhoea
**Diarrhoea
**Weight loss
**Increased appetite
*In contrast, '''horses''' with very little pancreatic tissue develop '''hypoinsulinism''' but rarely EPI