Difference between revisions of "Enteritis, Lymphocytic - Plasmacytic"
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==Signalment== | ==Signalment== | ||
*Often affects older animals but kittens of 16 weeks old and puppies of 20 weeks old have been reported. | *Often affects older animals but kittens of 16 weeks old and puppies of 20 weeks old have been reported. | ||
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==Description== | ==Description== | ||
| − | '''Lymphocytic - plasmacytic enteritis (LPE) | + | '''Lymphocytic - plasmacytic enteritis''' (LPE) is the most common form of [[Inflammatory Bowel Disease - WikiClinical|Inflammatory Bowel Disease]]. As its name suggests, the predominant cell type in the intestinal mucosa is '''lymphocytes''' and '''plasma cells'''. Enteric parasites, bacteria in dogs and ''Toxoplasma'' in cats have been reported to associated with LPE. This disorder in cats have also been shown to associate with concurrent disease of the pancreas and liver such as pancreatitis, cholangitis and hepatic lipidosis. This disease in animal has been compared to the human dsease. LPE is believed to be caused by an abnormal MALT response to luminal bacterial, dietary or self-antigens. |
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| + | The small intestines is affected to a variable degree of serverity. It has also been known to affect other parts of the gastrointestinal tract such as the stomach and the colon. In severely affected animals, this will result in a protein-losing enteropathy (PLE). | ||
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==Diagnosis== | ==Diagnosis== | ||
===Clinical Signs=== | ===Clinical Signs=== | ||
Most common: | Most common: | ||
| − | *small intestinal diarrhoea | + | *small intestinal diarrhoea. |
*weight loss | *weight loss | ||
*protein - losing enteropathy in severe cases | *protein - losing enteropathy in severe cases | ||
*chronic vomiting (more common presentation in cats compared to the other signs) | *chronic vomiting (more common presentation in cats compared to the other signs) | ||
| − | * | + | *Thickened small intestinal loops and mesenteric lymphadenopathy may be detected on physical examination in cats |
Others: | Others: | ||
| − | * | + | *Appetite changes |
| − | * | + | *Excessive borborygmi |
| − | * | + | *Abdominal discomfort |
| − | * | + | *Ascites or subcutaneous oedema if severe PLE resulting in hypoproteinaemia |
| − | * | + | *Concurrent systemic immune-mediated response and thromboembolism (rare) |
| + | |||
===Laboratory Tests=== | ===Laboratory Tests=== | ||
====Haematology==== | ====Haematology==== | ||
| − | *Panhypoproteinaemia (non- | + | *Panhypoproteinaemia (non-sepecific) |
====Biochemistry==== | ====Biochemistry==== | ||
| Line 33: | Line 41: | ||
====Other Tests==== | ====Other Tests==== | ||
| − | + | Serum trypsin-like immunoassay (TLI) to rule out exocrine pancreatic inssuficiency (EPI). | |
| − | + | ||
| + | Faecal analysis to rule out endoparasite and pathogenic bacteria. | ||
===Diagnostic Imaging=== | ===Diagnostic Imaging=== | ||
*Abdominal radiography is unremarkable, but it can be used to eliminate other differential diagnosis. | *Abdominal radiography is unremarkable, but it can be used to eliminate other differential diagnosis. | ||
| − | * | + | *Addominal ultrasonography may reveal thickened intestinal walls, mesenteric lymphadenopathy or abdominal effusion. |
===Histopathology=== | ===Histopathology=== | ||
| − | Intestinal biopsy is needed for a definitive | + | Intestinal biopsy is needed for a definitive diagbosis once all the other differential diagnoses have been eliminated. |
| + | |||
| + | Refer to [[Intestines Inflammatory Bowel Disease And Related Conditions - Pathology #Lymphocytic - Plasmacytic Enteritis|Lymphocytic - Plasmacytic Enteritis]] for pathology. | ||
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==Treatment== | ==Treatment== | ||
| − | + | ||
| + | |||
==Prognosis== | ==Prognosis== | ||
| − | + | ||
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*Hall, E.J, Simpson, J.W. and Williams, D.A. (2005) '''BSAVA Manual of Canine and Feline Gastroenterology (2nd Edition)''' ''BSAVA'' | *Hall, E.J, Simpson, J.W. and Williams, D.A. (2005) '''BSAVA Manual of Canine and Feline Gastroenterology (2nd Edition)''' ''BSAVA'' | ||
*Nelson, R.W. and Couto, C.G. (2009) '''Small Animal Internal Medicine (Fourth Edition)''' ''Mosby Elsevier''. | *Nelson, R.W. and Couto, C.G. (2009) '''Small Animal Internal Medicine (Fourth Edition)''' ''Mosby Elsevier''. | ||
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Revision as of 09:24, 12 August 2009
 |
This article is still under construction. |
Signalment
- Often affects older animals but kittens of 16 weeks old and puppies of 20 weeks old have been reported.
- Basenjis have been reported to suffer from a severe form known as immunoproliferative disease.
Description
Lymphocytic - plasmacytic enteritis (LPE) is the most common form of Inflammatory Bowel Disease. As its name suggests, the predominant cell type in the intestinal mucosa is lymphocytes and plasma cells. Enteric parasites, bacteria in dogs and Toxoplasma in cats have been reported to associated with LPE. This disorder in cats have also been shown to associate with concurrent disease of the pancreas and liver such as pancreatitis, cholangitis and hepatic lipidosis. This disease in animal has been compared to the human dsease. LPE is believed to be caused by an abnormal MALT response to luminal bacterial, dietary or self-antigens.
The small intestines is affected to a variable degree of serverity. It has also been known to affect other parts of the gastrointestinal tract such as the stomach and the colon. In severely affected animals, this will result in a protein-losing enteropathy (PLE).
Diagnosis
Clinical Signs
Most common:
- small intestinal diarrhoea.
- weight loss
- protein - losing enteropathy in severe cases
- chronic vomiting (more common presentation in cats compared to the other signs)
- Thickened small intestinal loops and mesenteric lymphadenopathy may be detected on physical examination in cats
Others:
- Appetite changes
- Excessive borborygmi
- Abdominal discomfort
- Ascites or subcutaneous oedema if severe PLE resulting in hypoproteinaemia
- Concurrent systemic immune-mediated response and thromboembolism (rare)
Laboratory Tests
Haematology
- Panhypoproteinaemia (non-sepecific)
Biochemistry
- Leucocytosis (non-specific)
Other Tests
Serum trypsin-like immunoassay (TLI) to rule out exocrine pancreatic inssuficiency (EPI).
Faecal analysis to rule out endoparasite and pathogenic bacteria.
Diagnostic Imaging
- Abdominal radiography is unremarkable, but it can be used to eliminate other differential diagnosis.
- Addominal ultrasonography may reveal thickened intestinal walls, mesenteric lymphadenopathy or abdominal effusion.
Histopathology
Intestinal biopsy is needed for a definitive diagbosis once all the other differential diagnoses have been eliminated.
Refer to Lymphocytic - Plasmacytic Enteritis for pathology.
Treatment
Prognosis
References
- Ettinger, S.J. and Feldman, E. C. (2000) Textbook of Veterinary Internal Medicine Diseases of the Dog and Cat Volume 2 (Fifth Edition) W.B. Saunders Company.
- Hall, E.J, Simpson, J.W. and Williams, D.A. (2005) BSAVA Manual of Canine and Feline Gastroenterology (2nd Edition) BSAVA
- Nelson, R.W. and Couto, C.G. (2009) Small Animal Internal Medicine (Fourth Edition) Mosby Elsevier.