Difference between revisions of "Intestinal Adenocarcinoma"
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− | Intestinal | + | Intestinal tumours account for less than 10% of all tumours in dogs and cats and 22% of gastrointestinal tumours in dogs and 35% in cats. [[Intestine Proliferative - Pathology #Adenocarcinoma|Adenocarcinoma]]/carcinoma is the most common malignant tumour in dogs and accounts for 17% of intestinal tumours in cats. |
==Signalment== | ==Signalment== | ||
+ | * Dogs: | ||
+ | ** Mean age: 6-9 years | ||
+ | ** Minor male predisposition | ||
+ | ** Large breeds may predominate particularly collies and German Sheperds | ||
− | + | * Cats: | |
+ | ** Mean age: 10-12 years | ||
+ | ** There are conflicting reports of whether there is a minor male predisposition | ||
+ | ** Siamese may have a breed predisposition | ||
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− | |||
− | + | ==Description== | |
+ | * No organism or chemical agent has been identified that will induce spontaneous intestinal adenocarcinoma. | ||
+ | * The gross appearance of colorectal adenocarcinomas vary from pedunculated, particularly in the distal rectum, cobblestone, in especially the middle rectum or annular, also usually in the middle recutum and may also have associations with tumour behaviour and prognosis. | ||
+ | * The most frequent sites of metastasis are the mesenteric lymph nodes. | ||
− | |||
− | + | ==Diagnosis== | |
+ | ===Clinical Signs=== | ||
+ | Often dependent on the site of the tumour within the gastrointestinal tract and include: | ||
+ | * For more proximal lesions: | ||
+ | ** vomiting | ||
+ | * For lesions within the small intestine: | ||
+ | ** Weight loss | ||
+ | * For tumours in the more distal tract: | ||
+ | ** Tenesmus | ||
+ | ** Hematochezia | ||
+ | * Other signs reported include: | ||
+ | ** Anorexia | ||
+ | ** Diarrhoea | ||
+ | ** Signs associated with intestinal obstruction, perforation and peritonitis | ||
+ | Associated paraneoplastic abnormalities include: | ||
+ | * Neutrophilic leukocytosis | ||
+ | * Monocytosis | ||
+ | * Eosinophilia | ||
+ | * Cutaneous disease | ||
+ | * Hyperviscosity syndromes | ||
− | + | ===Physical Examination=== | |
+ | * An abdominal mass may be palpable | ||
+ | * A mass may also be palpable via digital examination | ||
+ | * Cats may also be dehydrated | ||
− | === | + | ===Haematology and Biochemistry=== |
+ | Abnormalities observed include: | ||
+ | * Anaemia | ||
+ | * Leukocytosis | ||
+ | * Left shift | ||
+ | * Monocytosis | ||
+ | * Hypoproteinemia | ||
+ | * Raised hepatic enzymes | ||
+ | * High cholesterol | ||
+ | * Raised BUN - may be due to concurrent renal insufficiency, dehydration or absorption following intestinal bleeding | ||
− | + | ===Abdominal Radiography=== | |
+ | * An abdominal mass may be visible with plain radiography | ||
+ | * Alternatively evidence of obstruction may be observed | ||
+ | * Poor serosal detail may be apparent | ||
+ | * Contrast radiography can be useful for localising masses, revealing obstructions and filling defects and for intestinal areas more difficult to visualise via ultrasonography due to the accumulation of air. | ||
− | === | + | ===Thoracic Radiography=== |
+ | This is highly advised though presentation with pulmonary metastasis is infrequent. | ||
− | + | ===Abdominal Ultrasonography=== | |
+ | Is more sensitive than radiography in localising a mass and can assess involvement with the surrounding structures. In addition guided needle aspiration or biopsy may be taken at this time. Findings may include the following: | ||
+ | * Intestinal wall thickening with loss of wall layering - dogs with loss of layering are over 50 times more likely to have neoplastic disease rather than enteritis | ||
+ | * In cats, adenocarcinomas have been described as being of mixed echogenicity and are often asymmetric | ||
+ | * In dogs, adenocarcinomas have been described as being usually hypoechoic and most dogs had reduced motility | ||
− | + | ===Endoscopy and Laparoscopy=== | |
+ | Allow visualisation of the lesion. In addition, biopsies may be taken at this time, however, small samples only can be obtained thus there can be significant variation in the interepretation of the results. | ||
− | === | + | ===Exploratory Laparotomy=== |
− | + | If it has not been possible to make a definitive diagnosis using the above techniques then surgery is required. All abdominal tissues should be assessed and full thickness biopsies should be taken. Resection of the mass and intestinal anastomosis may be performed at this time. | |
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==Treatment== | ==Treatment== | ||
+ | ===Surgery=== | ||
+ | Resection and anastamosis is advised as primary treatment for intestinal adenocarcinoma. Complete excision can usually achieved, however extraserosal invasion or adhesions may cause difficulties. In the small intestine, stapling and suturing by hand have been shown to be equally efficient. Local excision of colorectal adenocarcinoma has a median survival time of 22 months while the use of stool softeners alone has a median survival time of 15 months. Perioperative complications include peritonitis and sepsis. There is significant perioperative risk associated with cats with small intestine adenocarcinoma with a high mortality rate within the first two weeks following surgery. However, after these two weeks long term control may be achieved. With large intestinal adenocarcinoma survival after surgery alone has been reported as approximately 4.5 months. | ||
− | + | ===Adjuvant Chemotherapy=== | |
+ | Doxirubicin as been shown to significantly improve survival times for cats with colonic adenocarcinoma with a median survival time of 56 and 280 days for those not receving and those receiving chemotherapy respectively. No other evidence exists to confirm the benefits of adjuvant chemotherapy in dogs or cats. | ||
− | + | ===Radiotherapy=== | |
− | + | Rarely reported due to concerns of intolerance of surrounding tissues, in addition it cannot be relied upon that the same target will be irratiated each day due to intestinal mobility. | |
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==Prognosis== | ==Prognosis== | ||
− | + | If no metastasis has occurred long term survival may be achieved following excision of the tumour. The rate of metastasis of adenocarcinoma to the local lymph nodes for both dogs and cats is approximately 50%. Without surgical intervention the mean survival of dogs with small intestinal adenocarcinoma is 12 days and reports varying from 114 days to 7-10 months with surgical treatment. Intensity of treatment is prognostic for colorectal tumours with palliative care carrying a poorer prognosis than local excision. In a small study males with small intestinal adenocarcinoma had a significantly better prognosis than females with the same disease. | |
− | If no metastasis has occurred long term survival may be achieved following | ||
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==References== | ==References== | ||
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Revision as of 13:36, 18 August 2009
This article is still under construction. |
Intestinal tumours account for less than 10% of all tumours in dogs and cats and 22% of gastrointestinal tumours in dogs and 35% in cats. Adenocarcinoma/carcinoma is the most common malignant tumour in dogs and accounts for 17% of intestinal tumours in cats.
Signalment
- Dogs:
- Mean age: 6-9 years
- Minor male predisposition
- Large breeds may predominate particularly collies and German Sheperds
- Cats:
- Mean age: 10-12 years
- There are conflicting reports of whether there is a minor male predisposition
- Siamese may have a breed predisposition
Description
- No organism or chemical agent has been identified that will induce spontaneous intestinal adenocarcinoma.
- The gross appearance of colorectal adenocarcinomas vary from pedunculated, particularly in the distal rectum, cobblestone, in especially the middle rectum or annular, also usually in the middle recutum and may also have associations with tumour behaviour and prognosis.
- The most frequent sites of metastasis are the mesenteric lymph nodes.
Diagnosis
Clinical Signs
Often dependent on the site of the tumour within the gastrointestinal tract and include:
- For more proximal lesions:
- vomiting
- For lesions within the small intestine:
- Weight loss
- For tumours in the more distal tract:
- Tenesmus
- Hematochezia
- Other signs reported include:
- Anorexia
- Diarrhoea
- Signs associated with intestinal obstruction, perforation and peritonitis
Associated paraneoplastic abnormalities include:
- Neutrophilic leukocytosis
- Monocytosis
- Eosinophilia
- Cutaneous disease
- Hyperviscosity syndromes
Physical Examination
- An abdominal mass may be palpable
- A mass may also be palpable via digital examination
- Cats may also be dehydrated
Haematology and Biochemistry
Abnormalities observed include:
- Anaemia
- Leukocytosis
- Left shift
- Monocytosis
- Hypoproteinemia
- Raised hepatic enzymes
- High cholesterol
- Raised BUN - may be due to concurrent renal insufficiency, dehydration or absorption following intestinal bleeding
Abdominal Radiography
- An abdominal mass may be visible with plain radiography
- Alternatively evidence of obstruction may be observed
- Poor serosal detail may be apparent
- Contrast radiography can be useful for localising masses, revealing obstructions and filling defects and for intestinal areas more difficult to visualise via ultrasonography due to the accumulation of air.
Thoracic Radiography
This is highly advised though presentation with pulmonary metastasis is infrequent.
Abdominal Ultrasonography
Is more sensitive than radiography in localising a mass and can assess involvement with the surrounding structures. In addition guided needle aspiration or biopsy may be taken at this time. Findings may include the following:
- Intestinal wall thickening with loss of wall layering - dogs with loss of layering are over 50 times more likely to have neoplastic disease rather than enteritis
- In cats, adenocarcinomas have been described as being of mixed echogenicity and are often asymmetric
- In dogs, adenocarcinomas have been described as being usually hypoechoic and most dogs had reduced motility
Endoscopy and Laparoscopy
Allow visualisation of the lesion. In addition, biopsies may be taken at this time, however, small samples only can be obtained thus there can be significant variation in the interepretation of the results.
Exploratory Laparotomy
If it has not been possible to make a definitive diagnosis using the above techniques then surgery is required. All abdominal tissues should be assessed and full thickness biopsies should be taken. Resection of the mass and intestinal anastomosis may be performed at this time.
Treatment
Surgery
Resection and anastamosis is advised as primary treatment for intestinal adenocarcinoma. Complete excision can usually achieved, however extraserosal invasion or adhesions may cause difficulties. In the small intestine, stapling and suturing by hand have been shown to be equally efficient. Local excision of colorectal adenocarcinoma has a median survival time of 22 months while the use of stool softeners alone has a median survival time of 15 months. Perioperative complications include peritonitis and sepsis. There is significant perioperative risk associated with cats with small intestine adenocarcinoma with a high mortality rate within the first two weeks following surgery. However, after these two weeks long term control may be achieved. With large intestinal adenocarcinoma survival after surgery alone has been reported as approximately 4.5 months.
Adjuvant Chemotherapy
Doxirubicin as been shown to significantly improve survival times for cats with colonic adenocarcinoma with a median survival time of 56 and 280 days for those not receving and those receiving chemotherapy respectively. No other evidence exists to confirm the benefits of adjuvant chemotherapy in dogs or cats.
Radiotherapy
Rarely reported due to concerns of intolerance of surrounding tissues, in addition it cannot be relied upon that the same target will be irratiated each day due to intestinal mobility.
Prognosis
If no metastasis has occurred long term survival may be achieved following excision of the tumour. The rate of metastasis of adenocarcinoma to the local lymph nodes for both dogs and cats is approximately 50%. Without surgical intervention the mean survival of dogs with small intestinal adenocarcinoma is 12 days and reports varying from 114 days to 7-10 months with surgical treatment. Intensity of treatment is prognostic for colorectal tumours with palliative care carrying a poorer prognosis than local excision. In a small study males with small intestinal adenocarcinoma had a significantly better prognosis than females with the same disease.