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|Drug - induced
|Drug - induced
|Non-steroidal anti-inflammatory drugs
|Non-steroidal anti-inflammatory drugs (NSAIDs)
|-
|-
|Idiopathic
|Idiopathic
|}
|}
Gastric ulceration is caused by damage to the gastric mucosa through the above mechanisms. NSAIDs directly damage the mucosa and interfere with the prostaglandin synthesis. Gastric ulceration is worsened by the use of NSAIDs in combination with corticosteroids. This risk can be minimised by using cyclooxygenase-1 (COX-1) sparing NSAIDs (carprofen, meloxicam and deracoxib.
Gastric acid hypersecretion following mast cell degranulation of histamine and gastrin secretion from gastrinomas is a major cause of gastric ulceration. Sled dogs and equine race horses are prone to gastric ulceration.
==Diagnosis==
==Diagnosis==
===History and Clinical Signs===
===History and Clinical Signs===
History may involve:
History may involve:
*Access to toxins and drugs such as non-steroidal anti-inflammatory drugs (NSAIDs)
*Access to toxins and drugs such as NSAIDs
Clinical Signs:
Clinical Signs:
*Vomiting
*Vomiting
*Circulatory comprimise
*Circulatory comprimise
===Haematology and biochemistry===
===Haematology===
===Biochemistry===
===Urinalysis===
===Plain radiography===
===Positive Contrast Radiography===
===Positive Contrast Radiography===
===Endoscopy and Biopsy===
===Endoscopy and Biopsy===
==Treatment==
===Fluid therapy===
===Acid-base correction===
==Treatment==
===Mucosal protectants===
===Prophylaxis===
===Anti-emetics===
===Analgesia===
===Other Medical Management===
===Antibiotics===
===Surgery===
==Prognosis==
==Prognosis==
Depends upon the cause
==References==
==References==